Case of Seizures With Sudden Discontinuation of Zolpidem

Mashiana, Manjot K; Irfanullah, Zakariya; Khawaja, Hamza; Khawaja, Alina Z; Khawaja, Imran S.

doi:10.4088/pcc.21cr02960

Cited by 3 publications

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“…Altas doses e a retirada abrupta do zolpidem podem levar a crises convulsivas, conforme diversos relatos de caso, entre eles Mashiana et al, que descreveram um caso de crise convulsiva após suspensão abrupta em uma paciente de 54 anos, usuária de 90-100mg diários de zolpidem [11]. Russo et al relataram um caso de um paciente de 29 anos, também com crises convulsivas após suspensão abrupta de 600mg diários de zolpidem [12].…”

Section: Discussionunclassified

Rabdomiólise secundária a convulsões induzidas por zolpidem

Carvalho

Weber

2023

Debates em Psiquiatria

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Introdução: Rabdomiólise é uma condição em que ocorre a destruição e necrose muscular. De etiologia variada, pode estar associada a crises convulsivas. O zolpidem é um agente sedativo e hipnótico não benzodiazepínico que sob condições de abuso e frequência pode ocasionar crises convulsivas. Relato de Caso: Homem, 26 anos, foi levado à emergência de hospital geral por ansiedade, onde apresentou episódios de crises convulsivas. Quadro evolui para rabdomiólise. História de abuso de zolpidem. Discussão: Altas doses de zolpidem alteram o agonismo seletivo no receptor benzodiazepina-1 e a retirada abrupta da medicação podem levar a crises convulsivas com evolução, em quadros graves, para rabdomiólise. Conclusões: A automedicação, e o uso abusivo de substâncias como zolpidem, apresentam potencial de causar tolerância e dependência podendo levar a quadros clínicos com risco a vida.

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Section: Discussionunclassified

Rabdomiólise secundária a convulsões induzidas por zolpidem

Carvalho

Weber

2023

Debates em Psiquiatria

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Zolpidem

2022

Reactions Weekly

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Strategies and Management for Psychiatric Drug Withdrawal: A Systematic Review of Case Reports and Series

Eserian,

Blanco,

Mercuri

et al. 2024

Pharmacopsychiatry

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In recent years, an increasing number of case reports on psychiatric drug withdrawal have emerged, offering detailed clinical insights and valuable real-world evidence on the withdrawal process. The objective of this review was to evaluate the strategies and management for withdrawing psychiatric drugs, as detailed in case reports and series. A systematic review of case reports and series published between 2013 and 2023 was conducted to capture the latest trends in psychiatric drug withdrawal. Cases were identified following the PRISMA guidelines by searching electronic databases Medline and Scopus. Finally, 47 case reports and series were included. The primary reason for drug withdrawal was attributed to the emergence of adverse events, followed by medication dependence or abuse, and clinical decision-making or symptom resolution. Gradual reduction of doses was implemented through various management approaches as the primary strategy for drug withdrawal, and drug substitution emerged as the second most employed strategy. Also, patients were mostly undergoing polypharmacy. Favorable treatment outcomes were reported in the majority of cases, suggesting that psychiatric drug withdrawal is feasible – though quite challenging in some situations. However, the remarkably low number of unsuccessful cases may create a misleading impression of the significant difficulty associated with withdrawing psychiatric drugs.

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Case of Seizures With Sudden Discontinuation of Zolpidem

Cited by 3 publications

References 0 publications

Rabdomiólise secundária a convulsões induzidas por zolpidem

Rabdomiólise secundária a convulsões induzidas por zolpidem

Zolpidem

Strategies and Management for Psychiatric Drug Withdrawal: A Systematic Review of Case Reports and Series

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