‘Case of the month’ from UConn Health, Farmington, CT, USA: management of a giant paraganglioma

Lyall, Vikram; Goltzman, Michael; Boutrous, Mina L.; Nallu, Ravali; Albertsen, Peter C.; Tendler, Beatriz; Ristau, Benjamin T.

doi:10.1111/bju.15248

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2022

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“…The size cutoff defining a giant PGL is not well described, and experience with these tumors has been derived mostly from case studies. 2 The incidence of giant RP PGLs is unknown, and largely their behavior can be inferred from literature describing metastatic PGL, as reports of localized giant PGLs have limited follow up. To our knowledge, this is the first report of bilateral giant PGL.…”

Section: Discussionmentioning

confidence: 99%

Management of SHDB positive patient with metastatic bilateral giant retroperitoneal paragangliomas

Strauss

Correa

Gong

et al. 2022

Urology Case Reports

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Paragangliomas are rare neuroendocrine tumors that can vary in size and metabolic activity. We report a case of giant bilateral malignant retroperitoneal paragangliomas (PGL) in a patient with germline succinate dehydrogenase B (SDHB) mutation. This patient, who presented in an emaciated and debilitated state, was managed with adrenergic blockade followed by radical primary surgery. After being metabolically and radiographically disease free for 4 years, he underwent salvage resection for recurrent retroperitoneal disease and palliative radiation to a site of solidary vertebral metastasis. We review incidence and prognosis of metastatic PGL.

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Section: Discussionmentioning

confidence: 99%