Case of the Season: Multiple Small Liver Lesions: An Important Differential

A Novel c.125 T>G (p.Val42Gly) Mutation in The Human INS Gene Leads to Neonatal Diabetes Mellitus via a Decrease in Insulin Synthesis

“…3) The intracellular trafficking of proinsulin through the Golgi apparatus to secretory granules allows it to be proteolytically processed by prohormone convertases (PC1/3 and PC2) and carboxypeptidase E (CPE) to form C peptide and mature insulin, which are stored in insulin-secretory granules and released upon stimulation [16][17][18].…”