Case-referent study on occupational risk factors for bladder cancer in southern Israel

Carel, Rafael S.; Levitas-Langman, A.; Kordysh, Ella; Goldsmith, John R.; Friger, Michael

doi:10.1007/s004200050379

Cited by 7 publications

(7 citation statements)

References 16 publications

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“…[1518192021] In our study, the proportion of persons with history of high risk occupations in case group was significantly more than control group with OR = 2.43 (1.37-4.33) [Table 5], this is comparable to other studies.…”

Section: Discussionsupporting

confidence: 87%

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Occupational risk of bladder cancer among Iranian male workers

et al. 2014

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Background:Approximately 5-10% of human cancers are thought to be caused by occupational exposure to carcinogens. Compare to other cancers, bladder cancer is most strongly linked to occupational exposure to chemical toxins. This study has been performed to understand which occupations and exposures are related to bladder cancer in Iran.Materials and Methods:This study is a case-control study which is conducted on cases with bladder cancer (160 cases) diagnosed in Baharlou hospital in 2007-2009. One hundred sixty cases without any occupational exposure were considered as controls matched for demographic characteristics. Demographic data and characteristics of occupation were compared.Results:Mean age of cases and controls were 63.7 and 64 years, respectively (P = 0.841). History of urinary tract stone had significantly difference in two groups (P = 0.039). Occupations such as bus and truck driving, road and asphalt making, mechanics, working in refinery and Petrochemical, plastic, metal manufactory, welding, and pipeline founded a higher risk for bladder cancer rather than controls.Conclusion:Our findings on Iranian workers are concurrent and compatible with findings of previous reports about occupational and environmental risk factors of bladder cancer. Although our study population was

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Section: Discussionsupporting

confidence: 87%

“…Compared to other cancers, bladder cancer is strongly linked to occupational exposure to chemicals. [202122] Approximately, 5-10% of human cancers are thought to be caused by occupational exposure to carcinogens. Compare to other cancers, bladder cancer is most strongly linked to occupational exposure to chemical toxins.…”

Section: Introductionmentioning

confidence: 99%

Occupational risk of bladder cancer among Iranian male workers

et al. 2014

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“…Bladder cancer is the fourth most common cancer in males and the ninth most common in females (Lagwinski et al, 2007;Scélo and Brennan., 2007;Yavari et al, 2009). It accounts for 7% of all new cancer cases, in men and 2% in women (Carel et al, 1999). Bladder cancer is almost three to four times more common in men than in women in most populations (Parkin et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Epidemiologic and Socioeconomic Status of Bladder Cancer in Mazandaran province, Northern Iran

Ahmadi

Ranjbaran²,

Amiri³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Asian Pacific J Cancer Prev, 13 (10), [5053][5054][5055][5056] IntroductionUrinary bladder cancer occurs in all countries around the world, and it is the fifth most common cancer in the United States (Oberfield et al., 1996;Ben-Kasus et al., 2005;Yamada et al., 2010). Bladder cancer is the second most common malignancy of the genitourinary tract worldwide after prostate cancer. However, in Iran, it is the most common cancer of the genitourinary system and the third most common cancer in males. The incidence of bladder cancer is lower in Asia as compare to Western European and North America (Johansson and Cohen, 1997).Globally, approximately 336,000 new cases of bladder cancer occurred in 2000, two-thirds of which were in developed countries. Bladder cancer is the fourth most common cancer in males and the ninth most common in females (Lagwinski et al., 2007;Scélo and Brennan., 2007;Yavari et al., 2009). It accounts for 7% of all new cancer cases, in men and 2% in women (Carel et al., 1999). Bladder cancer is almost three to four times more common in men than in women in most populations (Parkin et al., 2005). This reflects the more frequent exposure of men to . Demographic data, including sex, age, residency and symptoms were investigated through careful review of medical records. Using a questionnaire protocol, several variables were assessed for these cases such as smoking, history of opium, vegetable consumption habits, and history of other cancers. Results: A total of 112 cases were analyzed, 98 (87.5%) in men and 14 (12.5%) in women (mean age of 68.0±14.6 years). Urban and rural residence were 60.7% and 39.3%. Tobacco and opium use were found in 45.5% and 21.4% of patients, respectively. Approximately 60% consumed vegetables an average of fewer than one time per day. Hematuria was the first symptom in these cases which were mainly diagnosed as having bladder cancer by ultrasonography. Conclusion: The results showed that bladder cancer tends to be found in the elderly and the male to female ratio is high. Macroscopic hematuria is a very important symptom for indicating probably urothelial tumor that should be followed up patients with transabdominal ultrasonography as a routine modality.

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“…Cigarette smoking is the key factor contributing to bladder carcinoma in the United States 9. Among many case–control studies and a few cohort studies,10–25 the relative risk (RR) of bladder carcinoma for smokers versus nonsmokers varied between 1.2 and 6.3.…”

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confidence: 99%

Selective inhibition of cyclooxygenase 2–generated prostaglandin E₂ synthesis in rheumatoid arthritis synoviocytes by taurine chloramine

Kontny¹,

Rudnicka²,

Kowalczewski³

et al. 2003

Arthritis & Rheumatism

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Objective. To investigate the effects of taurine chloramine (Tau-Cl), a chlorinated derivative of the amino acid taurine, on the expression of cyclooxygenase (COX) isoenzymes and prostaglandin E 2 (PGE 2 ) synthesis in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS).Methods. FLS, isolated from the synovial tissue of RA patients, were treated in vitro with either interleukin-1␤ (IL-1␤; 1 ng/ml) alone or together with 200-500 M Tau-Cl. The expression of COX isoenzymes was evaluated at both the protein (Western blotting) and the messenger RNA (mRNA) (reverse transcriptase-polymerase chain reaction) levels. The concentration of PGE 2 was measured by competitive acetylcholinesterase enzyme immunoassay.Results. Resting FLS expressed mRNA encoding both COX-1 and COX-2, but only COX-1 was present at the protein level. These cells produced negligible amounts of PGE 2 . Upon stimulation with IL-1␤, elevation of COX-2, but not COX-1, mRNA and protein preceded the enhancement of PGE 2 synthesis. In the presence of 300-400 M Tau-Cl, significant inhibition of IL-1␤-triggered COX-2 mRNA and protein, and a related decrease in PGE 2 production, was observed. In contrast, no significant changes in COX-1 mRNA and protein levels were noted.Conclusion. Tau-Cl inhibits IL-1␤-triggered elevation of COX-2 and generation of PGE 2 by RA FLS. These results expand the spectrum of known antiinflammatory activities of this compound.

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Case-referent study on occupational risk factors for bladder cancer in southern Israel

Cited by 7 publications

References 16 publications

Occupational risk of bladder cancer among Iranian male workers

Occupational risk of bladder cancer among Iranian male workers

Epidemiologic and Socioeconomic Status of Bladder Cancer in Mazandaran province, Northern Iran

Selective inhibition of cyclooxygenase 2–generated prostaglandin E₂ synthesis in rheumatoid arthritis synoviocytes by taurine chloramine

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Case-referent study on occupational risk factors for bladder cancer in southern Israel

Cited by 7 publications

References 16 publications

Occupational risk of bladder cancer among Iranian male workers

Occupational risk of bladder cancer among Iranian male workers

Epidemiologic and Socioeconomic Status of Bladder Cancer in Mazandaran province, Northern Iran

Selective inhibition of cyclooxygenase 2–generated prostaglandin E2 synthesis in rheumatoid arthritis synoviocytes by taurine chloramine

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Selective inhibition of cyclooxygenase 2–generated prostaglandin E₂ synthesis in rheumatoid arthritis synoviocytes by taurine chloramine