Case Report: 18F-PSMA-1007 PET/CT Avid Solitary Penile Metastasis of Castration-Resistant Prostate Cancer With a PSA of 0.072 ng/ml

Abstract

Penile metastasis of prostate cancer is rare, with a poor prognosis, and only a limited number of relevant cases have been reported so far. With the application of 18F-PSMA-1007 PET/CT, the biochemical recurrence of prostate cancer can be detected at an early stage for providing important evidence, facilitating clinical decision-making. Here, we have reported a case of solitary penile metastatic recurrence in the context of mild PSA progression (PSA: 0.072 ng/ml). This case highlights the preferable sensitivity of 18F-PSMA-1007 PET/CT imaging in prostate cancer.

Unusual Presentation of Solitary Penile Metastasis of Prostate Cancer on 68Ga-PSMA PET/CT

“…[1][2][3] Few case reports presented penile metastasis postradical prostatectomy, which are however often associated with more disseminated systemic disease. [4][5][6][7] To our knowledge, this is the first case presented with solitary penile metastases diagnosed 3 years postradical resection of the primary tumor and adjuvant pelvic radiotherapy. Penile metastases depict negative prognosis, with limited median survival.…”

“…In the literature, most of the cases with penile metastases originating from genitourinary cancers were primarily treated with brachytherapy or external beam radiation of curative intent 1–3 . Few case reports presented penile metastasis postradical prostatectomy, which are however often associated with more disseminated systemic disease 4–7 . To our knowledge, this is the first case presented with solitary penile metastases diagnosed 3 years postradical resection of the primary tumor and adjuvant pelvic radiotherapy.…”

68Ga-PSMA-11 PET/CT and 64CuCl2 PET/CT Help in Identifying Rare Metastatic Site of Penile Shaft in a Patient of Carcinoma Prostate

“…There are a few case reports demonstrating this rare site of metastasis 2–4 . A few case reports in literature have reported the demonstration of the penile metastasis on PSMA PET/CT scans 5–9 . 64 CuCl 2 PET/CT imaging is under evaluation for imaging various oncological conditions including carcinoma prostate 10–12 .…”