Case Report: A Fatal Case of West Nile Virus Meningoencephalomyelitis in a Woman with Systemic Lupus Erythematosus Initially Misdiagnosed as SARS-CoV-2 Infection

Schiuma, Marco; Pezzati, Laura; Ballone, Elisabetta; Borghi, Beatrice; Osio, Maurizio; Mattavelli, Daniele; Galimberti, Laura; Corbellino, Mario; Mileto, Davide; Zanchetta, Nadia; Antinori, Spinello

doi:10.4269/ajtmh.21-0041

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…Afterwards, histopathologic and immunohistochemical investigation of lung nodules con rmed the diagnosis of poorly differentiated neoplasm suggestive of angiosarcoma positive for CD34, CD31, negative staining by PanCK, CAM5. (9)(10)(11)(12); among these is a case of cardiac liposarcoma recurrence with symptoms of dyspnea, palpitation, fever, and sore throat (10). Unfortunately, many cases of cardiac angiosarcoma are not timely diagnosed despite multimodality workups such as echocardiography, chest CT scan, HRCT, and biopsy, due to a broad spectrum of differential diagnoses such as benign tumors, viral, mycobacterial, or rheumatologic diseases being investigated (13).…”

Section: Case Presentationmentioning

confidence: 99%

Primary Cardiac Angiosarcoma With Pulmonary Metastasis in a Young Female: A Case Report and Review of Literature

Kordjazy

Taheri

Parkhideh

et al. 2022

Preprint

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Background: Sarcomas are the most prevalent type of malignant primary cardiac tumor. Clinical presentation differs according to the size and location of the tumor and involvement of other structures. Case presentation: In this article, we present a 38 years old lady as a case of primary cardiac angiosarcoma with a huge challenge in diagnosis and management of the disease. On the 4th of June 2020, she emergently presented to the hospital with the chief complaint of cough and tachypnea, diarrhea, and malaise, and a history of blunt chest trauma three weeks ago. Based on the presentation and transthoracic echocardiography which was compatible with cardiac tamponade, emergent pericardiocentesis was performed. The first imaging showed bilateral pleural effusion, pericardial effusion, and no significant parenchymal lung involvement, which was not compatible with rheumatologic diseases or COVID-19. Based on cardiac CT angiography and evidence of dye entrance to the peri-right atrial area, right atrial free wall rupture was suspected as the cause of the massive pericardial effusion. Following multidisciplinary consensus, she underwent cardiac surgery; in addition to the 3*3 cm right atrium free wall rupture repair, concomitant sampling from the lung nodules, lymph nodes, pericardium, and also the surrounding tissue of the right atrium ruptured defect was performed. Based on immunohistochemistry, the diagnosis was compatible with cardiac angiosarcoma with metastasis to the lung. Due to the advanced stage of the tumor, oncologists advised against chemotherapy or radiotherapy and she went through palliative care. Finally, after a 53-day ICU stay and due to right-sided heart failure, the patient unfortunately died. Conclusion: COVID-19 pandemic has brought diagnostic challenges regarding differentiating SARS-CoV-2 infection from other diagnostic entities. On the other hand, due to the rarity and fatality of primary cardiac angiosarcomas, early diagnosis and possible management seem crucial for prolonged survival. Involving cardiac angiosarcoma in the initial differential diagnosis could warrant timely diagnosis and assessment of various therapies for cure or palliative care.

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Section: Case Presentationmentioning

confidence: 99%

Primary Cardiac Angiosarcoma With Pulmonary Metastasis in a Young Female: A Case Report and Review of Literature

Kordjazy

Taheri

Parkhideh

et al. 2022

Preprint

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“…Cases of arbovirus infection being misdiagnosed and treated like other diseases such as malaria, hepatitis, measles, and coronavirus diseases 2019 (COVID-19) have been reported. [17][18][19][20][21][22] In a study by Schiuma and colleagues, WNV infection being misdiagnosed for COVID-19 in an Egyptian woman has been reported. 22…”

Section: Important Arboviral Diseasesmentioning

confidence: 99%

“…[17][18][19][20][21][22] In a study by Schiuma and colleagues, WNV infection being misdiagnosed for COVID-19 in an Egyptian woman has been reported. 22…”

Section: Important Arboviral Diseasesmentioning

confidence: 99%

Tackling the global health threat of arboviruses: An appraisal of the three holistic approaches to health

Tajudeen

Oladunjoye

Mustapha

et al. 2021

Health Promot Perspect

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Background: The rapid circulation of arboviruses in the human population has been linked with changes in climatic, environmental, and socio-economic conditions. These changes are known to alter the transmission cycles of arboviruses involving the anthropophilic vectors and thus facilitate an extensive geographical distribution of medically important arboviral diseases, thereby posing a significant health threat. Using our current understanding and assessment of relevant literature, this review aimed to understand the underlying factors promoting the spread of arboviruses and how the three most renowned interdisciplinary and holistic approaches to health such as One Health, Eco-Health, and Planetary Health can be a panacea for control of arboviruses. Methods: A comprehensive structured search of relevant databases such as Medline, PubMed, WHO, Scopus, Science Direct, DOAJ, AJOL, and Google Scholar was conducted to identify recent articles on arboviruses and holistic approaches to health using the keywords including "arboviral diseases", "arbovirus vectors", "arboviral infections", "epidemiology of arboviruses", "holistic approaches", "One Health", "Eco-Health", and "Planetary Health" Results: Changes in climatic factors like temperature, humidity, and precipitation support the growth, breeding, and fecundity of arthropod vectors transmitting the arboviral diseases. Increased human migration and urbanization due to socio-economic factors play an important role in population increase leading to the rapid geographical distribution of arthropod vectors and transmission of arboviral diseases. Medical factors like misdiagnosis and misclassification also contribute to the spread of arboviruses. Conclusion: This review highlights two important findings: First, climatic, environmental, socio-economic, and medical factors influence the constant distributions of arthropod vectors. Second, either of the three holistic approaches or a combination of any two can be adopted on arboviral disease control. Our findings underline the need for holistic approaches as the best strategy to mitigating and controlling the emerging and reemerging arboviruses.

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“…On the rise of the overwhelming pandemic, there has been reported evidence of West Nile fever misdiagnosed as COVID-19 in concurrent PCR positive patients. [3] Eye pain, rhabdomyolysis, hepatitis, myocarditis, central diabetes insipidus, fetal hemorrhagic fever, myositis are less common complications. Similarly, the neuroinvasive form involves meningitis, encephalitis, flaccid paralysis, convulsions with neurological presentations.…”

Section: Dear Editormentioning

confidence: 99%

West Nile Fever amid COVID-19 Crisis

Waleed

Agrawal

Sadiq

et al. 2021

OJMS

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Case Report: A Fatal Case of West Nile Virus Meningoencephalomyelitis in a Woman with Systemic Lupus Erythematosus Initially Misdiagnosed as SARS-CoV-2 Infection

Cited by 4 publications

References 9 publications

Primary Cardiac Angiosarcoma With Pulmonary Metastasis in a Young Female: A Case Report and Review of Literature

Primary Cardiac Angiosarcoma With Pulmonary Metastasis in a Young Female: A Case Report and Review of Literature

Tackling the global health threat of arboviruses: An appraisal of the three holistic approaches to health

West Nile Fever amid COVID-19 Crisis

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