Case Report: A giant but silent adrenal pheochromocytoma – a rare entity

Munakomi, Sunil; Rajbanshi, Saroj; Adhikary, Shailesh

doi:10.12688/f1000research.8168.1

Cited by 10 publications

(9 citation statements)

References 15 publications

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“…Tumours over 20 cm have rarely been described in the literature 4. The largest recorded adrenal pheochromocytoma was reported by Basso, in which they removed a 29x21x12 cm tumour attached to a normal left adrenal gland 5.…”

Section: Discussionmentioning

confidence: 99%

Giant cystic pheochromocytoma

Cajipe

González

Kaushik³

2017

BMJ Case Reports

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A 56-year-old healthy woman presents with 2-year history of symptoms classic for pheochromocytoma. Evaluation revealed one of the largest cystic pheochromocytomas reported but without any metastatic disease. After achieving medical management of her symptoms, surgical removal was performed successfully and without any complications intraoperatively. Pathology of the mass confirmed the diagnosis. The patient had complete resolution of her symptoms thereafter.

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Section: Discussionmentioning

confidence: 99%

Giant cystic pheochromocytoma

Cajipe

González

Kaushik³

2017

BMJ Case Reports

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“…1,2,11,17 Surgical resection followed by postoperative monitoring is the safest and the most effective therapeutic intervention for pheochromocytoma. 1,2,4,9,11,14,18 Although there are several reports on pheochromocytoma from centres in developed countries, 19−22 there is limited information available from developing regions of the world such as sub-Saharan Africa. This is probably related to limited healthcare resources and laboratory facilities for the diagnosis of pheochromocytoma in Africa.…”

Section: Introductionmentioning

confidence: 99%

Characteristics and outcome of patients with pheochromocytoma at a tertiary endocrinology clinic in Durban, South Africa over 14 years

Zorgani

Pirie

Motala

2018

Journal of Endocrinology, Metabolism and Diabetes of South Afri

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To evaluate the characteristics and outcomes of treatment of patients with pheochromocytoma at Inkosi Albert Luthuli Central Hospital (ILACH) in Durban, South Africa over 14 years. Design: Retrospective chart review. Setting and subjects: Patients with pheochromocytoma attending the endocrinology clinic at IALCH between 2012 and 2016 were studied. Outcome measures: Clinical, biochemical and radiological data were collected at presentation, on discharge, one year and five years after surgical intervention; tumour characteristics, histopathological features and surgical outcome were also assessed. Results: The analysis included 35 patients (mean age 33.2 ± 15.7 years; 60% female). Headache (68.6%), palpitation (60%) and sweating (57.6%) were the three most common presenting symptoms; hypertension was the predominant clinical finding (85.7%). Most pheochromocytomas were sporadic (82.9%), adrenal gland tumours (68.6%) and benign (77.1%); of eight patients with malignant tumours, two were familial. Adrenalectomy was undertaken in the majority (n = 34; 97.1%); 55.2% were large tumours. The use of adjunctive radiotherapy (n = 4; 11.4%) and chemotherapy (n = 1; 2.9%) was low. There was low overall mortality (5.7%), but 57.6% developed intraoperative hypotension. At one year postoperatively, 80% (n = 28) of patients were defined as cure, biochemically in 23 (82.1%) and with radiology in five (17.9%). Conclusions: Most patients presenting to IALCH had large intra-abdominal tumours with high cure rate, low mortality but a high rate of perioperative complications. Late presentation and large tumour size was a feature.

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“…Lots of catecholamine will be released in blood, resulting in hypertensive crisis. [4][5][6] In this case, the patient had no obvious continuous hypertension, but only had the vague abdominal sign. The abdominal CT only reminded the huge tumor in the left upper abdominal cavity and behind peritoneum.…”

Section: Discussionmentioning

confidence: 74%

Case report: A Re-operation Case of Asymptomatic Left Giant Pheochromocytoma and Literature Review

Dai

Liu

Dai

et al. 2020

Preprint

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Introduction: Pheochromocytoma (PCC) is a rare tumor which derives from adrenal medulla, when maximum diameter of pheochromocytoma is greater than 10CM, it is divided into Giant pheochromocytoma(GPCC), which is extremely rare and usually asymptomatic.Clinically, a huge and asymptomatic adrenal pheochromocytoma was usually misdiagnosed as other types of tumors, which result in notable increase of complication rates and death rates.Case presentation:In this case report, we described a clinically asymptomatic GPCC patient. Diagnosis:According to computed tomography (CT) scan, nuclear magnetic resonance(MR) scan, the patient is initially diagnosed as liposarcoma.After laparotomy, biochemical detection of catecholamine (CA) intermediate metabolites methoxyepinephrine (MN) and methoxy norepinephrine (NMN) and the pathological examination , diagnosis of GPCC was obtained. Intervention：The laparotomy was suspended and a diagnosis of pheochromocytoma was confirmed, because of unstable blood pressure and hypertension during separating and moving the mass during surgery. After consultation of multi-disciplinary team, adequate preoperative preparation was conducted according to the procedure of PCC surgical preparation. By the end of the regular phenoxybenzamine and intravenous fluids treatment for three weeks, the blood pressure of the patient was kept at an acceptable average. Therefore, the patient underwent the operationagain for radical resection. Outcome: After the operation, CA was basically normal in rechecking process, and the tumor was successfully removed. Pathological diagnosis of the mass after operation: Immunohistochemical resulted conformed to (epigastrium) pheochromocytoma. Immunohistochemistry: CgA(+), Inhibin-α(-), ki-67(<1%+), Syn(+). Pheochromocytoma had the definite pathological diagnosis. Conclusion: GPCC has the high diagnostic identification difficulty, it should be combined with imaging examination and biochemical measurement to identify. Before operation, the detailed imageological examination provides important reference for excision and surgical planning. Individualized and multi-disciplinary cooperation of management strategy in perioperative period should be recommended. Patients should conduct long-term follow-up.

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Case Report: A giant but silent adrenal pheochromocytoma – a rare entity

Cited by 10 publications

References 15 publications

Giant cystic pheochromocytoma

Giant cystic pheochromocytoma

Characteristics and outcome of patients with pheochromocytoma at a tertiary endocrinology clinic in Durban, South Africa over 14 years

Case report: A Re-operation Case of Asymptomatic Left Giant Pheochromocytoma and Literature Review

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