Case Report: A Left Donor Lung Implanted in the Recipient’s Right Thorax for the Therapy of Pulmonary Fibrosis

Chen, J.Y.; Zheng, Mingming; Jing, Zhao; Wang, Y.G.; Zhu, Qianqian; Chen, Ranxun

doi:10.1016/j.transproceed.2006.03.030

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…In deceased-donor lung transplantation, several surgical modifications have been performed to counter the severe donor shortage worldwide, such as pulmonary bipartitioning, lobar transplantation, and inverted left lung transplantation into the right thorax (12)(13)(14)(15)(16). In LDLLT, native lungsparing bilateral LDLLT and single LDLLT with contralateral lung resection also have been reported (17,18); however, there are no reports of right and left inverted lobar lung transplantation.…”

Section: Discussionmentioning

confidence: 99%

Right and Left Inverted Lobar Lung Transplantation

Chen

Miyamoto

Takemoto

et al. 2015

American Journal of Transplantation

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Adult recipients frequently withdraw from livingdonor lobar lung transplantation because of the small size of donor grafts. The right lower lobe is 120% larger than the left lower lobe. We developed a novel surgical technique in which an inverted right lower lobe graft can be transplanted into the left thorax. The first patient was a 43-year-old woman with end-stage idiopathic interstitial pneumonia. Her husband was the only eligible donor for living-donor lobar lung transplantation. His right lower lobe was estimated to provide 45% of the recipient's predicted forced vital capacity, which would provide the borderline function required for living-donor lobar lung transplantation. Since lung perfusion scintigraphy of the recipient showed a right-to-left ratio of 64:36, transplanting the right lower lobe graft into the left thorax and sparing the native right lung was considered the only treatment option. We simulated this procedure using three-dimensional models produced by a three-dimensional printer. In living-donor lobar lung transplantation, all anastomoses were performed smoothly as planned preoperatively. Because of the initial success, this procedure was performed successfully in two additional patients. This procedure enables larger grafts to be transplanted, potentially solving critical size matching problems in livingdonor lobar lung transplantation.

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Section: Discussionmentioning

confidence: 99%

Right and Left Inverted Lobar Lung Transplantation

Chen

Miyamoto

Takemoto

et al. 2015

American Journal of Transplantation

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Initial Experience of Lung Transplantation at a Single Center in China

Mao¹,

Chen²,

Zheng³

et al. 2013

Transplantation Proceedings

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Heterotopic lung transplant: a feasible approach to compensate for organ shortages

Zhao

Liu

et al. 2022

Interactive CardioVascular and Thoracic Surgery

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Lung transplantation is still limited by the shortage of suitable donor lungs, especially during the COVID-19 pandemic. Heterotopic lung transplantation (HLTx), as a flexible surgical procedure, can maximize the potential of donor lungs in an emergency, but its wide spread is hindered by difficulties in anastomosis and paucity of outcome data. Retrospective review of four patients receiving HLTx over 1 year, including 1 left-to-right single HLTx, 2 right-to-left single HLTxs, and 1 lobar HLTx (right upper lobe-to-left). Median recipient age was 58.5 years (46–68), and 3 patients were male. Post-operative hospital stay was 33 days (30–42). One recipient lived for 10 years and died of bronchiolitis obliterans syndrome, others were alive with no major morbidity at 12 to 31 months after operation with a 1-year survival of 100%. The follow-up chest imaging showed transplanted lungs could be inflated well and adapt morphologically to fill the thoracic cavity in short and long term. This study demonstrates that HLTx, as a feasible alternative to conventional lung transplantation in emergency cases, could be considered in selected patients at advanced medical centers.

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Case Report: A Left Donor Lung Implanted in the Recipient’s Right Thorax for the Therapy of Pulmonary Fibrosis

Cited by 3 publications

References 3 publications

Right and Left Inverted Lobar Lung Transplantation

Right and Left Inverted Lobar Lung Transplantation

Initial Experience of Lung Transplantation at a Single Center in China

Heterotopic lung transplant: a feasible approach to compensate for organ shortages

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