Case Report: A Rare Case of Nasal Forehead Mass in Kimura's Disease

He, Zuyuan; Cao, Zhiwei; Gu, Zhaowei

doi:10.3389/fsurg.2021.672291

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…Kimura’s disease is a rare chronic inflammatory disorder which typically presents with painless subcutaneous mass of the head and neck, often accompanied by involvement of large salivary glands or nearby lymph nodes. 1 , 2 Frequently seen in young men, Kimura’s disease is usually featured by elevated serum IgE and peripheral blood eosinophilia. 3 Currently, the preferred treatment strategy for Kimura’s disease is not well established.…”

Section: Introductionmentioning

confidence: 99%

Multiomic landscape of immune pathogenesis in Kimura’s disease

Wu¹,

Wang²,

Wang³

et al. 2023

iScience

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Section: Introductionmentioning

confidence: 99%

Multiomic landscape of immune pathogenesis in Kimura’s disease

Wu¹,

Wang²,

Wang³

et al. 2023

iScience

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“… 12 The disease has a low incidence and is a chronic immune disease causing lymph node, soft tissue, and salivary gland damage. 12 , 13 In some cases, Kimura disease may be associated with renal damage, and treatment is mainly hormonal. The combination of Kimura disease with C. albicans meningitis has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Case Report: Successful Treatment of Recurrent Candida Albicans Meningitis with Kimura’s Disease Using Amphotericin B Colloidal Dispersion Combined with Fluconazole

Shen,

Zhou,

Zhang

et al. 2023

IDR

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Background Candida albicans meningitis is a fungal infectious disease of the central nervous system that most often occurs in immunodeficient populations. Kimura’s disease is an IgE-mediated inflammatory reactive disease that is a chronic immune disorder with predominantly lymph node, soft tissue, and salivary gland damage, the treatment of which is hormone-based. The combination of Kimura’s disease with C. albicans meningitis is relatively uncommon. Herein, we report a case of C. albicans meningitis in combination with Kimura’s disease. Case Presentation The case is a 26-year-old male with a medical history of Kimura, who presented with symptoms of dizziness, headache, and double vision. Lumbar puncture and cerebrospinal fluid examination revealed an increased white blood cell count. Further analysis through cerebrospinal fluid culture and metagenomic second-generation sequencing (mNGS) led to the final diagnosis of C. albicans meningitis. The patient was treated with fluconazole after the onset of C. albicans meningitis and had a good response. During the treatment, changes in the pathogen genome sequences were monitored dynamically using metagenomic next-generation sequencing. After 1 year, the patient had a recurrence of Candida meningitis. Treatment with fluconazole alone was ineffective, while antifungal treatment with amphotericin B colloidal dispersion was effective with no detectable renal injury. Conclusion Candida meningitis can occur in the context of Kimura disease. In patients with mild disease, the possibility of recurrence exists with fluconazole treatment alone, and the efficacy of amphotericin B colloidal dispersion combined with fluconazole is better than fluconazole alone in patients with a recurrence. No nephrotoxicity was observed during amphotericin B colloidal dispersion treatment. The mNGS allows dynamic monitoring of pathogen sequencing reads, and for Candida meningitis, there may be a mismatch between peak sequencing reads and disease during treatment, the basis for which is unclear.

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Kimura disease: comprehensive analysis of clinical features, comorbidities, and treatment approaches

Zhu,

Zhang,

Zhang

et al. 2024

Preprint

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Background Kimura disease (KD) is a rare, chronic, inflammatory disorder characterized by painless subcutaneous masses, lymphadenopathy, elevated eosinophil counts and increased serum immunoglobulin E (IgE) levels. Due to the heterogeneity and rarity, current diagnostic and treatment approaches for KD are often delayed and have limited efficacy. Methods The clinicopathological data of 51 KD patients between January 2014 and December 2023 were retrieved and stratified based on age and mass size, respectively. A case ofrecurrent KD who responded well to a low dose of mepolizumab was described. Results We found that pruritus occurred in 45.8% of patients, with higher rates in older patients (P=0.033). Edema was observed in 29.2%, with higher prevalence in younger patients (P=0.010). The mean maximum mass size was 3.1cm, varying by age group (P=0.005). The mean time to diagnosis was 36 months, increasing with mass size (P=0.024). Meanwhile, we reported that one of these 51 patients was successfully treated with mepolizumab at a dose of 100mg every 4 weeks. Conclusion We conclude that pruritus and edema are the two main clinical manifestation of KD, and the size of mass is related to the time of diagnosis. Biologic agents targeting the Th2 pathway show promise for KD treatment.

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Case Report: A Rare Case of Nasal Forehead Mass in Kimura's Disease

Cited by 3 publications

References 19 publications

Multiomic landscape of immune pathogenesis in Kimura’s disease

Multiomic landscape of immune pathogenesis in Kimura’s disease

Case Report: Successful Treatment of Recurrent Candida Albicans Meningitis with Kimura’s Disease Using Amphotericin B Colloidal Dispersion Combined with Fluconazole

Kimura disease: comprehensive analysis of clinical features, comorbidities, and treatment approaches

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