Case Report: An Incidental Finding of Fahr's Disease in a Patient with Hypochondria

Abstract

Idiopathic basal ganglia calcification (IBGC), commonly referred to as Fahr’s disease, is a rare neurological disorder characterized by the abnormal, symmetrical, and bilateral calcification of the basal ganglia and other brain regions. Patients typically present in their forties and fifties with various neurologic and/or psychiatric symptoms, including movement disorders, Parkinsonism, psychosis, and depression.The pathophysiology of this disease is not completely understood; however, several gene mutations have been identified in the pathogenesis of Fahr’s disease. These mutations display an autosomal dominant inheritance pattern. Furthermore, the regional phenotypic expression of calcifications differs greatly from patient to patient, as do their clinical presentations. Here, we describe a patient who presented with psychiatric manifestations and imaging consistent with Fahr’s disease.

rare case of Fahr's syndrome with dissociative amnesia

“…According to previous research, mood disorder, psychotic symptoms, and cognitive disturbance are the most common features (Calabrò et al, 2014;El Hechmi et al, 2014;Naqvi et al, 2017;Roiter et al, 2016). An incidental finding of FD in a hypochondriac patient was also reported in previous research (Samuels et al, 2018). In addition, there was an unusual and previously unreported presentation of fugue, retrograde memory loss, and autobiography amnesia in our case.…”

“…FS with depression, delusional-manic disorder, dementia, flattening of affectivity, hypochondria, and schizophrenia was reported in previous research (Calabrò et al, 2014;El Hechmi et al, 2014;Naqvi et al, 2017;Roiter et al, 2016;Samuels et al, 2018;Savino et al, 2016). Furthermore, parathyroid endocrinopathies and Parkinsonism can be pathognomonic, but FS has no pathognomonic psychiatric symptoms.…”