Case Report: Ceftriaxone-Resistant Invasive Salmonella Enteritidis Infection with Secondary Hemophagocytic Lymphohistiocytosis: A Contrast with Enteric Fever

Banday, Aaqib Zaffar; Mehta, Rajesh; Vignesh, Pandiarajan; Kanaujia, Rimjhim; Durgadevi, S.; Angrup, Archana; Kumar, Narender; Ray, Pallab; Suri, Deepti

doi:10.4269/ajtmh.20-0566

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…Bacter ia l i n fections associated to H LH have frequently been reported in tropical countries and include Brucella (72,(107)(108)(109), Salmonella enteritidis (73,90,110), Tuberculosis (88,90,111), sepsis by streptococcal infection [group B streptococcus (112) and Streptococcus suis (113)], by Listeria (72) or without identified pathogen (90). Orientia tsutsugamushi, the causing agent of scrub typhus, has been reported in India (73,89,90) and Korea (114)(115)(116)(117).…”

Section: Classificationmentioning

confidence: 99%

Secondary hemophagocytic lymphohistiocytosis in children (Review)

et al. 2023

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Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening condition characterized by hyperinflammation in an uncontrolled and ineffective immune response. Despite great improvement in diagnosis and treatment, it still represents a challenge in clinical management, with poor prognosis in the absence of an aggressive therapeutic approach. The present literature review focuses on secondary HLH at pediatric age, which represents a heterogeneous group in terms of etiology and therapeutic approach. It summarizes the most recent evidence on epidemiology, pathophysiology, diagnosis, treatment and prognosis, and provides a detailed description and comparison of the major subtypes of secondary HLH. Finally, it addresses the open questions with a focus on diagnosis and new treatment insights.

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