Case report: Chondrosarcoma of the head and neck

Quevedo, Francisco Carlos; Quevedo, Fernando Batocchio; Neto, José Carlos Barauna; Ferreira, Elisa Napolitano; Carraro, Dirce Maria; Soares, Fernando Augusto

doi:10.1016/j.ehpc.2015.07.002

Cited by 11 publications

(19 citation statements)

References 8 publications

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“…The maxilla is the most affected bone and usually has slow growth, but it can be locally aggressive with a high rate of recurrence. Other primary sites in the head or neck are the jaw, nasal cavity and maxillary sinus [5], the present case was reported in the left maxillary sinus.…”

Section: Discussionmentioning

confidence: 60%

“…Evan's and co-workers have attempted to associate the histologic grade (Grade I to III) of chondrosarcoma with the ultimate biologic behavior of the tumor, depending upon the cellularity, nuclear size, and presence of mitotic figures, multinucleation, spindle cell formation and mineralization in the form of osseous development at the edge of the cartilaginous lobules [9]. We used the WHO (2013) [5] classification of bone tumors (grades I-III).We also add that in bone sarcomas, the histologic subtype often determines grade. For example, mesenchymal chondrosarcoma and the dedifferentiated chondrosarcoma are always considered high grade [5].…”

Section: Discussionmentioning

confidence: 99%

“…We used the WHO (2013) [5] classification of bone tumors (grades I-III).We also add that in bone sarcomas, the histologic subtype often determines grade. For example, mesenchymal chondrosarcoma and the dedifferentiated chondrosarcoma are always considered high grade [5]. Immunohistochemically, chondroid areas are positive for vimentin and CD99, but not for S-100 protein [7,10].…”

Section: Discussionmentioning

confidence: 99%

“…In such cases, the concomitant chemo radiation CCR therapy can be used to decrease the size of the tumor and making the definitive therapy more effective, as we show here in the present case. Radiation is performed for palliative cases, unresectable cases or as an adjunctive therapy in cases of residual disease, but not as an initial or single treatment [5].…”

Section: Discussionmentioning

confidence: 99%

“…Tumor recurrence is relatively common and usually occurs due to an incomplete resection of the tumor. It also may be due to the local spread of the disease or surgical technique issues [5]. The overall 5-year survival for low grade chondrosarcoma after complete resection is between 55-75% [14].…”

Section: Discussionmentioning

confidence: 99%

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Mesenchymal Chondrosarcoma of the Maxillary Sinus: Reporting Case with Good Response to Radiotherapy

Mahfoudi¹

2019

IJNMRS

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Introduction: Mesenchymal chondrosarcoma (MC) is a rare variant of chondrosarcoma (CS) that accounts for up to 3-10% of all CS. The head and neck localization is rare and may involve the sinonasal tract, jaws, larynx or skull base. It has been described as an aggressive neoplasm with high tendency for recurrences and delayed metastasis. Case report:We reported a case of a 41-years-old women complaining of right facial pain. Examination revealed hemorrhagic mass with bucco-palatal extension and causing displacement upper 2nd premolar teeth. Computed tomography (CT) scan revealed a lytic tumor arising of the left maxillary bone and extending into the orbit and the infratemporal fossae. Transoral biopsy was performed according to Caldwell luc technique. Histological examination and immunohistological study confirmed the diagnosis of high grade MC .Since the tumor was unresectable, the treatment was definitive concomitant chemoradiation (CCR) at the dose of 64Gy over 46 days by intensity modulation radiation therapy (IMRT), with a good response. The patient remains free of disease 12 months after treatment. After that she had a recurrent non metastatic disease, Combination chemotherapy with vincristine, doxorubicin, cyclophosphamide, ifosfamide, Mesna and etoposide was administered. Conclusion:MC of the sinonasal tract is an aggressive tumor with a predilection for young women. Recurrences develops in approximately one-third of patients and seems to predict a poor prognosis. Multimodal treatment based on surgery radiation and chemotherapy appears to improve clinical outcome.

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Section: Discussionmentioning

confidence: 60%