Case report: Clinical and radiological features of Cogan's syndrome — Non-syphilitic interstitial keratitis, audiovestibular symptoms and systemic manifestations

Thomas, H.G.

doi:10.1016/s0009-9260(05)81006-2

Cited by 22 publications

(7 citation statements)

References 4 publications

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“…The disorder has also been described in patients with inflammatory bowel disease [24, 25]. The differential diagnosis of CS includes diverse conditions that cause similar eye and inner ear manifestations (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Interstitial Keratitis, Vertigo, and Vasculitis: Typical Cogan’s Syndrome

Ahad

Maleki

Hormozi

et al. 2014

Case Reports in Medicine

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Cogan's syndrome (CS) is a chronic inflammatory disorder of unknown etiology that most commonly affects young adults. Clinical hallmarks are bilateral interstitial keratitis and vestibuloauditory dysfunction. Association between CS and systemic vasculitis as well as aortitis also exists. The diagnosis of CS is based upon presence of characteristic inflammatory eye disease and vestibuloauditory dysfunction. We describe classic Cogan's syndrome in a 47-year-old female from Ardabil. The patient was admitted with headache, vertigo, nausea, vomiting, right leg claudication, musculoskeletal pains, bilateral hearing loss, and blindness for the past two months. Ophthalmologic examination revealed that visual acuity was 0.1 bilaterally. Conjunctival hyperemia, bilateral cataract, and interstitial keratitis were detected with a slit lamp examination. Pure tone audiogram (PTA) and auditory brain stem response (ABR) showed bilateral sensorineural hearing loss. The other differential diagnosis of CS was studied and ruled out. Pulse i.v. methylprednisolone and cyclophosphamide were given and were followed by oral prednisolone and cyclophosphamide. Clinical follow-up showed partial improvement.

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Section: Discussionmentioning

confidence: 99%

Interstitial Keratitis, Vertigo, and Vasculitis: Typical Cogan’s Syndrome

Ahad

Maleki

Hormozi

et al. 2014

Case Reports in Medicine

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“…Eğer tedaviye erken dönemde başlanmazsa koklea ossifiye olabilir ve geri dönüşümsüz işitme kaybı gelişebilir. Hastalığın ilerleyen döneminde vestibüler semptomlar düzelirken, genellikle her iki tarafta işitme azalır ve tipik Cogan sendromunda %54, atipik formda ise %37 sensorinöral işitme kaybı gelişebilir (12,13) .…”

Section: Discussionunclassified

A Rare Inflammatory Disease: Cogan' s Syndrome

Karaaslan¹,

Gürakan²,

Kalçın³

et al. 2016

BUCH

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Cogan sendromu, ender görülen, nedeni bilinmeyen, özellikle görme ve işitmeyi etkileyen inflamatuvar bir hastalıktır. İnterstisyel keratit ve işitme kaybı bulguları ile karakterize olup, orta ve büyük damarları etkileyen vaskülitler tabloya eşlik edebilir. Bu olgu sunumunda, kliniğimize görme ve işitme yakınmaları ile başvurmuş ve Cogan sendromu tanısı almış 14 yaşında bir erkek hasta sunulmuştur.

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“…Manifestations of aortitis are most often aneurysm formation, but aortic wall thickening alone also has been reported (Tseng et al 1999;Balink and Bruyn 2007;Bisdas et al 2009;Kondo et al 2009). Aneurysmal disease also has been reported (or identified in published illustrations) in the carotid, intracerebral, subclavian, brachiocephalic, and renal arteries (Thomas 1992;Albayram et al 2001;Gaubitz et al 2001;Low et al 2007;Bisdas et al 2009). Occlusive arterial disease is relatively frequently reported to involve the aortic arch branches, the arteries of the abdominal viscera, the iliac arteries, extremity arteries, coronary arteries, and rarely intracerebral arteries (Raza et al 1998;Tseng et al 1999;Albayram et al 2001;Sandner et al 2009;Weyn et al 2009).…”

Section: Arterial Findings Of Vasculitis In Cogan's Syndromementioning

confidence: 96%

“…3, 4) (Low et al 2007). Because foci of arterial wall necrosis may be present in Cogan's syndrome vasculitis, pseudoaneurysm formation must be anticipated, identified, and treated to prevent rupture (Thomas 1992). Bypass grafting or endovascular stenting are treatment options.…”

Section: Surgery and Endovascular Treatmentmentioning

confidence: 99%

“…Balloon angioplasty or stent placement and lysis of thrombus are alternative endovascular techniques (Allen et al 1990;Bastug et al 1997). Such occlusive lesions amenable to endovascular treatment may occur in any primary or secondary artery (Vollertsen et al 1986;Allen et al 1990;Thomas 1992;Vella et al 1997;Tseng et al 1999;Bisdas et al 2009). …”

Section: Surgery and Endovascular Treatmentmentioning

confidence: 99%

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