Case Report: Clinical application of continuous arterial infusion chemotherapy in neoadjuvant therapy for locally advanced gastric cancer

Abstract

Platinum-fluorouracil combination chemotherapy is the standard neoadjuvant treatment for locally advanced gastric cancer in China, but it does not improve the survival benefit of patients. In recent years, the application of immune checkpoint inhibitors and/or targeted drugs in neoadjuvant therapy for gastric cancer has achieved certain efficacy, but the survival benefit of patients is still not obvious. Intra-arterial infusion chemotherapy, as a method of regional therapy, has been widely used in the treatment of many advanced tumors and achieved remarkable curative effect. The role of arterial infusion chemotherapy in neoadjuvant therapy for gastric cancer is not clear. We describe two patients with locally advanced gastric cancer treated with continuous arterial infusion neoadjuvant chemotherapy. Two patients received continuous arterial infusion of chemotherapy drugs for 50 hours, the drugs were pumped into the main feeding artery of the tumor through the arterial catheter. A total of 4 cycles were followed, then undergone surgical resection. The postoperative pathological pCR of two patients was 100%, TRG was 0 grade, and no further anti-tumor therapy was required after operation, achieving clinical cure. During the treatment period, no serious adverse events occurred in either patient. These results suggest that continuous arterial infusion chemotherapy may be a new adjuvant therapy for locally advanced gastric cancer.

Evaluation of oxaliplatin and tigio combination therapy in locally advanced gastric cancer

“…After gastroscopy and pathological examination, these tumors are often found in the middle and late stages, thus losing the best period for surgery[ 20 ]. Neoadjuvant chemotherapy has become a new treatment method for some patients with middle and advanced malignant tumors in recent years, aiming to control and shrink the progression of the lesions through chemotherapy and then achieve therapeutic purpose through surgical treatment[ 21 ]. This type of therapy mainly uses a combination of two or three drugs; however, the number of drugs must be selected according to the patient’s body indicators and tolerance before treatment[ 22 ].…”