Case Report: Collision Tumour of Colon Leiomyosarcoma and Adenocarcinoma

Kim, Victoria M.; Goicochea, Lindsay; Fang, Sandy H.

doi:10.7860/jcdr/2016/16949.7956

Cited by 9 publications

(9 citation statements)

References 7 publications

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“…Duffy et al suggested that management options should be more aggressive concerning CT with major neuroendocrine components (51). Given their rare nature, CTs of the colon do not have standards for treatment and prognosis (52). All the patients in our study underwent surgical removal of their tumors.…”

Section: Discussionmentioning

confidence: 92%

Collision Tumors of the Gastrointestinal Tract: A Systematic Review of the Literature

et al. 2018

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Background/Aim: Collision tumors are rare neoplasms which consist of two or more distinct neoplasms that develop adjacent to one another and coexist with no or minimal intermingling between them. Their diagnosis is often incidental and their behavior remains widely unknown. Several theories have been proposed regarding their pathogenesis. The objective of this study was the evaluation of current evidence on collision tumors of the gastrointestinal tract regarding their pathology, biological behavior and treatment approach. Materials and Methods: The PubMed and Cochrane bibliographical databases were searched from January 1997 to July 2018 (last search: July 5th, 2018) for studies reporting on collision tumors of the gastrointestinal tract that also included a therapeutic approach. Results: Forty-seven studies reporting on collision tumors of the gastrointestinal tract were identified. They reported collectively on 53 cases (43 males, 10 females) with collision tumors of the esophagus, stomach, small intestine and large intestine. The vast majority (96.2%) of tumors consisted of two distinct histological components and only two cases involved a greater number of histological subtypes. Fifty-one patients underwent a surgical or endoscopic tumor resection, accompanied in 22 cases by adjuvant or neoadjuvant therapy. The remaining two patients underwent palliative operations. In total, three patients experienced immediate postoperative complications. Conclusion: Collision tumors of the gastrointestinal tract, despite their rare nature, constitute a quite interesting field of study. This review offers a thorough insight into the clinicopathological characteristics and biological behavior of these rare tumors.

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Section: Discussionmentioning

confidence: 92%

Collision Tumors of the Gastrointestinal Tract: A Systematic Review of the Literature

et al. 2018

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“…Collision of the two malignancies can occur between tumors originating in the same organ or between metastases from other sites [4]. In literature, collision tumors of the colon consist of a combination of adenoma or adenocarcinoma with lymphoma, neuroendocrine tumors or leiomyosarcoma [1][2][3]. To the best of our knowledge, this is the first case of a colon collision tumor composed of adenocarcinoma and IMT.…”

Section: Discussionmentioning

confidence: 99%

“…In literature, collision tumors which have occurred in the colon consist of a combination of adenoma or adenocarcinoma with lymphoma, neuroendocrine tumors or leiomyosarcoma [1][2][3]. Here, we report the first case of a collision tumor composed of colon adenocarcinoma and an inflammatory myofibroblastic tumor (IMT).…”

Section: Introductionmentioning

confidence: 98%

Collision Tumor Composed of an Inflammatory Myofibroblastic Tumor and Adenocarcinoma of the Colon: a Rare Entity

Cornacchia

Rutigliani

Belli

et al. 2020

JGLD

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This report presents the case of an 83-year old man with a collision tumor consisting of an inflammatory myofibroblastic tumor (IMT) and adenocarcinoma of the left colon. As the clinical and radiologic features of IMT are non-specific, only the accurate histopathological examination from the left hemicolectomy specimen was diagnostic. Although the prognosis of a colorectal IMT seemed more favorable than in other sites, four months after surgery the patient developed a tumor relapse. Therefore, malignant behavior of IMT could not be totally excluded. Recent studies have demonstrated that a chromosomal rearrangement involving 2p23, the site of the anaplastic lymphoma kinase (ALK) gene, is present in a subset of these tumors. In our patient, tumor cells did not present ALK-1 perinuclear positivity and it could have indicated a less favorable prognosis. The collision of these different entities is extremely rare and this is the first case reported in literature. Further cases of collision tumors with clinical information including their treatment and prognosis are needed.

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“…There are only 11 publications describing collision tumors with pancreatic involvement with a collision between ductal adenocarcinoma and neuroendocrine tumor both of the pancreas being the most frequently described [1–11]. There are only 8 publications describing a collision tumor with any sarcoma involved [10–17]. In those cases liposarcoma and leiomyosarcoma are the two most frequently mentioned entities.…”

Section: Discussionmentioning

confidence: 99%

First reported case of a collision tumor composed of pancreatic adenocarcinoma and retroperitoneal liposarcoma: a case report

et al. 2018

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BackgroundCollision tumors are rare cases with two different tumor entities growing synchronously. While adenocarcinoma of the pancreas is the most common pancreatic tumor with an incidence of 10 per 100.000, retroperitoneal liposarcoma remains very rare. This is the first report of a collision tumor between these two tumor entities.Case presentationDemographic details:The tumor was diagnosed in a 64 male Caucasian patient. Besides atrial fibrillation, arterial hypertension and a hypothyroidism there is no relevant medical history especially no history of cancer.Clinical details:During a routine check-up an unclassified tumor of the pancreatic tail was diagnosed. The lab showed no pathologies. Tumor markers were negative for carbohydrate antigen 19–9 and 72–4 (CA 19–9, CA 72–4) and carcinoembryonic antigen (CEA). Alpha-fetoprotein (AFP) and neuron specific enolase (NSE) were both elevated (AFP 97kU/l, (< 5,8kU/l) and NSE 30,0 μg/l (16,4 μg/l)). A computed tomography-guided core needle biopsy was performed which revealed a low-grade liposarcoma (G1). A CT scan showed no metastases. A surgical resection was recommended by the interdisciplinary tumor board.Interventions: A systematic left sided retroperitoneal compartment resection including en-bloc-left sided pancreatectomy, splenectomy, nephrectomy, hemicolectomy, adrenalectomy, partial gastrectomy and partial resection of the diaphragm was performed. Pathology revealed a collision tumor consisting of pancreatic adenocarcinoma that was classified pT3, pN2 (11/33 ece+) L1 V0 Pn0, R0; G2 [UICC Stage III] and a liposarcoma pT2, pN0 (0/33) L0 V0 Pn0, G1 [UICC Stage Ib].The postoperative tumor board recommended an adjuvant chemotherapy with gemcitabine and capecitabine for the locally advanced pancreatic adenocarcinoma.Outcome: At the latest follow-up (1 year after surgery) the patient was in good clinical condition and without evidence of tumor recurrence.ConclusionCollision tumors are rare and difficult to diagnose. This is the first description of a collision tumor composed of pancreatic adenocarcinoma and retroperitoneal liposarcoma.The reported case demonstrates that inconsistent diagnostic results (e.g. imaging and pathology) should raise suspicion concerning the diagnosis. Awareness of these rare cases might protect us from underdiagnosing patients and therefore leading to better patient care.There is evolving evidence that will lead to more personalized treatment options for somatic BRCA mutated pancreatic cancer.Electronic supplementary materialThe online version of this article (10.1186/s12885-018-5151-6) contains supplementary material, which is available to authorized users.

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Case Report: Collision Tumour of Colon Leiomyosarcoma and Adenocarcinoma

Cited by 9 publications

References 7 publications

Collision Tumors of the Gastrointestinal Tract: A Systematic Review of the Literature

Collision Tumors of the Gastrointestinal Tract: A Systematic Review of the Literature

Collision Tumor Composed of an Inflammatory Myofibroblastic Tumor and Adenocarcinoma of the Colon: a Rare Entity

First reported case of a collision tumor composed of pancreatic adenocarcinoma and retroperitoneal liposarcoma: a case report

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