Case Report: Cystic Fibrosis, Lung Transplantation, and the Novel H1N1 Flu

Bresci, S.; Borchi, Beatrice; Ambu, Silvia; Taccetti, Giovanni; Braggion, C.; Leoncini, F.

doi:10.1016/j.transproceed.2010.05.028

Cited by 3 publications

(2 citation statements)

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“…In this patient population, fever may be the most consistent indicator, though nausea and vomiting have been typical as well 7. Our study does support that these symptoms may indicate 2009 H1N1 influenza, though it is concerning that the symptomatology may not manifest itself early in the disease process, if at all.…”

Section: Discussionsupporting

confidence: 43%

“…Subsequent reports on 2009 H1N1 in transplantation have highlighted the inconsistency of signs and symptoms at presentation, the necessity for early recognition and treatment, the potential for intensive care unit (ICU) admission and mechanical ventilation, and the risk for mortality 3–7. Yet these reports do not address the long-term impact of respiratory viral illnesses (RVIs) in lung transplantation, which have been associated with bronchiolitis obliterans syndrome (BOS) and death 8–10.…”

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confidence: 99%

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Challenges in the Diagnosis of 2009 H1N1 in a Lung Transplant Patient and the Long-Term Implications for Prevention and Treatment: A Case Report

Davis

Deburghgraeve

Yong

et al. 2010

Transplantation Proceedings

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Although respiratory viral infections have been associated with acute rejection and bronchiolitis obliterans syndrome, the long-term impact of the novel pandemic influenza A (2009 H1N1) virus on lung transplant patients has not been defined. We describe the diagnostic challenges and longterm consequences of 2009 H1N1 infection in a lung transplant patient, discuss the potential implications for prevention and treatment, and conclude that even timely antiviral therapy may be insufficient to prevent long-term morbidity.

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Section: Discussionsupporting

confidence: 43%

mentioning

confidence: 99%

Challenges in the Diagnosis of 2009 H1N1 in a Lung Transplant Patient and the Long-Term Implications for Prevention and Treatment: A Case Report

Davis

Deburghgraeve

Yong

et al. 2010

Transplantation Proceedings

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Current World Literature

2011

Current Opinion in Pulmonary Medicine

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The Role of Everolimus in Lung and Liver Transplantation

2011

Clinical Medicine Reviews in Therapeutics

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Everolimus (ERL) is a recently developed mTOR inhibitor. This rapamycin analog is used to prevent acute rejection during kidney and heart transplantation. We review here published clinical trials and experiences concerning potential applications of ERL in liver and lung transplantation. Most of the data concern conversion for rescue situations, but a small number of studies have been conducted in de novo patients. In most cases, everolimus was used to spare renal function and to minimize calcineurine inhibitor use, but also, due to the antiproliferative properties of the drugs of this class, to control malignancy. Safety issues are an important consideration when deciding whether to maintain a patient on treatment. Therapeutic drug monitoring is strongly recommended, to achieve a mean whole-blood trough concentration of 6 ng/mL, with doses of 0.5 to 1.5 mg administered twice daily. There is solid evidence that ERL is a feasible and effective treatment, for a selected subset of patients, in the contexts of liver and lung transplantation.

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Case Report: Cystic Fibrosis, Lung Transplantation, and the Novel H1N1 Flu

Cited by 3 publications

References 3 publications

Challenges in the Diagnosis of 2009 H1N1 in a Lung Transplant Patient and the Long-Term Implications for Prevention and Treatment: A Case Report

Challenges in the Diagnosis of 2009 H1N1 in a Lung Transplant Patient and the Long-Term Implications for Prevention and Treatment: A Case Report

Current World Literature

The Role of Everolimus in Lung and Liver Transplantation

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