Case Report: Cystitis Glandularis Mimics Bladder Tumour: A Case Report and Diagnostic Characteristics

Lee, G; Tsiriopoulos, I.; Yajnik, K; Smith, R C; Pancharatnam, M.

doi:10.1007/s11255-005-1665-3

Cited by 7 publications

(5 citation statements)

References 3 publications

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“…Cystitis glandularis has been reported as a potential mimic of bladder adenocarcinoma [14, 15]. Histologically, it is composed of glands in the lamina propria, which are lined by cuboidal to columnar cells surrounded by one or more layers of urothelial cells.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum

Zarineh

Bulakhtina

Olson

et al. 2009

Case Reports in Medicine

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Villous adenomas of the urinary tract are an uncommon, well-recognized entity, described in different locations. However, the occurrence of this lesion in the female urethral diverticulum is very unusual. We present the first case of a recurrent villous adenoma with high-grade dysplasia unassociated with adenocarcinoma, arising from a urethral diverticulum. A 75-year-old African-American female presented with urethral prolapse complaining of mild voiding difficulty, stress incontinence, and mild spotting of blood. Histological examination revealed a papillary lesion with finger-like processes lined by pseudostratified columnar epithelium with abundant goblet cells. There were focal areas with stratification to the luminal surface and loss of nuclear polarity and atypical mitoses, interpreted as villous adenoma with high-grade dysplasia. The lesion recurred at one year without evidence of malignant transformation. We also present a brief literature review of urothelial villous adenomas.

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Section: Discussionmentioning

confidence: 99%

Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum

Zarineh

Bulakhtina

Olson

et al. 2009

Case Reports in Medicine

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“…At cystoscopy, the mucosa usually has a cobblestone pattern. In addition, cystitis glandularis may develop into a papillary or polypoid mass (Fig 16), a form that mimics carcinoma, with a predilection for the bladder neck and trigone (30,31). In young patients, their age should raise the suspicion that the lesion might be nonneoplastic, but biopsy is necessary for a definitive diagnosis.…”

Section: Cystitis Cystica and Cystitis Glandularismentioning

confidence: 99%

Inflammatory and Nonneoplastic Bladder Masses: Radiologic-Pathologic Correlation

Wong-You-Cheong

Woodward²,

Manning³

et al. 2006

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Although the vast majority of bladder tumors are epithelial neoplasms, a variety of nonneoplastic disorders can cause either focal bladder masses or diffuse mural thickening and mimic malignancy. Some of these entities are rare and poorly understood such as inflammatory pseudotumor, which produces ulcerated, bleeding polypoid bladder masses. These masses may be large and have an extravesical component. Bladder endometriosis manifests as submucosal masses with characteristic magnetic resonance imaging features consisting of hemorrhagic foci and reactive fibrosis. Nephrogenic adenoma has no typical features, and pathologic evaluation is required for diagnosis. Although imaging features of malacoplakia are also nonspecific, characteristic Michaelis-Gutmann bodies are found at pathologic evaluation. The various types of cystitis (cystitis cystica, cystitis glandularis, and eosinophilic cystitis) require pathologic diagnosis. Bladder infection with tuberculosis and schistosomiasis produces nonspecific bladder wall thickening and ulceration in the acute phase and should be suspected in patients who are immunocompromised or from countries where these infections are common. The diagnosis of chemotherapy cystitis and radiation cystitis should be clinically evident, but imaging may be used to determine severity and to assess complications. Extrinsic inflammatory diseases such as Crohn disease and diverticulitis may be associated with fistulas to the bladder and focal bladder wall abnormality. The extravesical findings allow the diagnosis to be made easily. Finally, extrinsic masses arising from the prostate or distal ureter may cause filling defects, which can be confused with intrinsic bladder masses.

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“…Cystitis cystica, ureteritis cystica, and cystitis glandularis can be observed as polypoid filling defects on radiographs. In longstanding infections, a cellular reaction to dead ova produces calcification and fibrosis, which are important contributors to squamous metaplasia and squamous cell carcinoma (25,26).…”

Section: Histopathologic Findingsmentioning

confidence: 99%

“…At cystoscopy in patients with either of these forms of cystitis, the mucosa usually has a cobblestone-like appearance. In addition, in late-stage cystitis glandularis, a papillary or polypoid mass may arise that mimics carcinoma and demonstrates a predilection for the bladder neck and trigone (25,26).…”

Section: Schistosomal Bladdermentioning

confidence: 99%

Genitourinary Schistosomiasis: Life Cycle and Radiologic-Pathologic Findings

Shebel¹,

Elsayes²,

Atta³

et al. 2012

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Genitourinary schistosomiasis is produced by Schistosoma haematobium, a species of fluke that is endemic to Africa and the Middle East, and causes substantial morbidity and mortality in those regions. It also may be seen elsewhere, as a result of travel or immigration. S haematobium, one of the five fluke species that account for most human cases of schistosomiasis, is the only species that infects the genitourinary system, where it may lead to a wide spectrum of clinical symptoms and signs. In the early stages, it primarily involves the bladder and ureters; later, the kidneys and genital organs are involved. It rarely infects the colon or lungs. A definitive diagnosis of genitourinary schistosomiasis is based on findings of parasite ova at microscopic urinalysis. Clinical manifestations and radiologic imaging features also may be suggestive of the disease, even at an early stage: Hematuria, dysuria, and hemospermia, early clinical signs of an established S haematobium infection, appear within 3 months after infection. At imaging, fine ureteral calcifications that appear as a line or parallel lines on abdominopelvic radiographs and as a circular pattern on axial images from computed tomography (CT) are considered pathognomonic of early-stage schistosomiasis. Ureteritis, pyelitis, and cystitis cystica, conditions that are characterized by air bubble-like filling defects representing ova deposited in the ureter, kidney, and bladder, respectively, may be seen at intravenous urography, intravenous ureteropyelography, and CT urography. Coarse calcification, fibrosis, and strictures are signs of chronic or late-stage schistosomiasis. Such changes may be especially severe in the bladder, creating a predisposition to squamous cell carcinoma. Genital involvement, which occurs more often in men than in women, predominantly affects the prostate and seminal vesicles.

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Case Report: Cystitis Glandularis Mimics Bladder Tumour: A Case Report and Diagnostic Characteristics

Cited by 7 publications

References 3 publications

Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum

Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum

Inflammatory and Nonneoplastic Bladder Masses: Radiologic-Pathologic Correlation

Genitourinary Schistosomiasis: Life Cycle and Radiologic-Pathologic Findings

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