Case Report: Disseminated Edwardsiella tarda infection in an immunocompromised patient

An, Lucia; Chan, June L.; Nguyen, Margaret; Yang, Shangxin; Deville, Jaime G.

doi:10.3389/fcimb.2023.1292768

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…Clinical isolates of E. tarda are uniformly susceptible to aminoglycosides, ampicillin, ampicillin/sulbactam, βlactam antibiotics (cephalosporins), β-lactamase-inhibitor agents, carbapenems, quinolones, aztreonam, and chloramphenicol. Such in vitro studies are supported by recent case studies [155,168,169] and one retrospective survey of E. tarda bacteremia in Japan [149] yielding identical results. The term "pan-susceptible" has been coined in referring to this unusual highly susceptible Edwardsiella species [155].…”

Section: Antimicrobial Susceptibility 71 E Tarda Susceptibility Profi...supporting

confidence: 56%

“…Such in vitro studies are supported by recent case studies [155,168,169] and one retrospective survey of E. tarda bacteremia in Japan [149] yielding identical results. The term "pan-susceptible" has been coined in referring to this unusual highly susceptible Edwardsiella species [155]. While the vast majority (>90%) of E. tarda strains have also been found to be susceptible to both tetracycline class compounds and trimethoprim-sulfamethoxazole, rare resistant isolates have been detected in vitro or in vivo [197,198].…”

Section: Antimicrobial Susceptibility 71 E Tarda Susceptibility Profi...supporting

confidence: 56%

“…Two unusual syndromes have been reported on multiple occasions predisposing people to E. tarda septicemia. Cushing's syndrome or a cushingoid-like condition has been described in two cases of E. tarda bacteremia occurring in an 18-year-old man and a 20-year-old woman [154,155]. In both instances, multiple organ sites were involved including the liver and peritoneum in addition to blood.…”

Section: Septicemiamentioning

confidence: 99%

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Expanding the Spectrum of Diseases and Disease Associations Caused by Edwardsiella tarda and Related Species

Janda,

Duman

2024

Microorganisms

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The genus Edwardsiella, previously residing in the family Enterobacteriaceae and now a member of the family Hafniaceae, is currently composed of five species, although the taxonomy of this genus is still unsettled. The genus can primarily be divided into two pathogenic groups: E. tarda strains are responsible for almost all human infections, and two other species (E. ictaluri, E. piscicida) cause diseases in fish. Human infections predominate in subtropical habitats of the world and in specific geospatial regions with gastrointestinal disease, bloodborne infections, and wound infections, the most common clinical presentations in decreasing order. Gastroenteritis can present in many different forms and mimic other intestinal disturbances. Chronic gastroenteritis is not uncommon. Septicemia is primarily found in persons with comorbid conditions including malignancies and liver disease. Mortality rates range from 9% to 28%. Most human infections are linked to one of several risk factors associated with freshwater or marine environments such as seafood consumption. In contrast, edwardsiellosis in fish is caused by two other species, in particular E. ictaluri. Both E. ictaluri and E. piscicida can cause massive outbreaks of disease in aquaculture systems worldwide, including enteric septicemia in channel catfish and tilapia. Collectively, these species are increasingly being recognized as important pathogens in clinical and veterinary medicine. This article highlights and provides a current perspective on the taxonomy, microbiology, epidemiology, and pathogenicity of this increasingly important group.

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Section: Antimicrobial Susceptibility 71 E Tarda Susceptibility Profi...supporting

confidence: 56%

Section: Antimicrobial Susceptibility 71 E Tarda Susceptibility Profi...supporting

confidence: 56%

Section: Septicemiamentioning

confidence: 99%

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Expanding the Spectrum of Diseases and Disease Associations Caused by Edwardsiella tarda and Related Species

Janda,

Duman

2024

Microorganisms

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High‐Efficiency Genome Editing in Naturally Isolated Aeromonas hydrophila and Edwardsiella Piscicida Using the CRISPR‐Cas9 System

Feng,

Ma,

Zhang

et al. 2024

Biotech & Bioengineering

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Aeromonas hydrophila and Edwardsiella piscicida are significant bacterial pathogens in aquaculture, causing severe diseases and tremendous economic losses worldwide. Additionally, both of them can act as opportunistic pathogens in humans, leading to severe infections. Efficient genome editing tools for these pathogens are essential for understanding their pathogenic mechanisms and physiological behaviors, enabling the development of targeted strategies to control and mitigate their effects. In this study, we adapted the CRISPR‐Cas9 system for high‐efficiency, marker‐less genome editing in multiple naturally isolated strains of these two aquaculture pathogens. We developed a streamlined procedure that successfully generated deletion mutants of the aerA gene (encoding for aerolysin, a pore‐forming toxin that plays a critical role in the pathogenicity) and the gfp insertion mutants in three naturally isolated A. hydrophila strains. Additionally, we deleted five putative hemolysin‐encoding genes in both A. hydrophila ML10‐51K and its ∆aerA derivative. The same system was also applied to the naturally isolated E. piscicida S11‐285 strain, successfully deleting the ssaV gene (a component of the Type III Secretion System—a critical virulence mechanism in many pathogenic bacteria). The methodologies developed herein could be broadly applied to other pathogenic strains from natural environments, providing valuable tools for studying bacterial pathogenesis and aiding in the development of effective control strategies.

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mNGS-identified cellulitis due to quinolone-resistant Edwardsiella tarda: a case report

Wang,

Gu,

Zhang

et al. 2024

Front. Med.

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Edwardsiella tarda is frequently isolated from aquatic animals and environments. While human infections caused by E. tarda are rare, some extraintestinal infections can be severe. This case report describes a patient with cellulitis of the right upper extremity of unknown origin. Metagenomic next-generation sequencing (mNGS) indicated that the patient was infected with E. tarda. Antimicrobial susceptibility testing revealed that the isolate was resistant to quinolones and trimethoprim/sulfamethoxazole. The isolate, positive for four virulence genes (fimA, gadB, mukF, and sodB), was confirmed to be virulent using the Galleria mellonella larvae model. Following early pus drainage and a 9-day course of imipenem, the patient ultimately recovered. This case report aimed to illustrate the presentation, diagnosis, and management of uncommon cellulitis caused by drug-resistant, virulent E. tarda.

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Case Report: Disseminated Edwardsiella tarda infection in an immunocompromised patient

Cited by 4 publications

References 30 publications

Expanding the Spectrum of Diseases and Disease Associations Caused by Edwardsiella tarda and Related Species

Expanding the Spectrum of Diseases and Disease Associations Caused by Edwardsiella tarda and Related Species

High‐Efficiency Genome Editing in Naturally Isolated Aeromonas hydrophila and Edwardsiella Piscicida Using the CRISPR‐Cas9 System

mNGS-identified cellulitis due to quinolone-resistant Edwardsiella tarda: a case report

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