Case report: Disseminated Scedosporium apiospermum infection with invasive right atrial mass in a heart transplant patient

Bourlond, Baudouin; Cipriano, Ana; Regamey, Julien; Papadimitriou‐Olivgeris, Matthaios; Kamani, Christel H.; Seidel, Danila; Lamoth, Frédéric; Müller, Olivier; Yerly, Patrick

doi:10.3389/fcvm.2022.1045353

Cited by 6 publications

(1 citation statement)

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“…Of these, 18 were single case reports and 3 were cohort studies providing individual BDG data for a small number of cases (1–4 patients) ( Supplementary Figure 1 ). 18 , 23 , 56–74 In total, 27 cases of proven or probable IS (16 scedosporiosis, 10 lomentosporiosis, and 1 mixed infection) in patients with EORTC–MSGERC host factors were included. The characteristics of the patients and IS cases are described in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

Performance of the beta-glucan test for the diagnosis of invasive fusariosis and scedosporiosis: a meta-analysis

et al. 2023

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The (1→3)-β-D-glucan (BDG) is a component of the fungal cell wall that can be detected in serum and used as an adjunctive tool for the diagnosis of invasive mold infections (IMI) in patients with hematologic cancer or other immunosuppressive conditions. However, its use is limited by modest sensitivity/specificity, inability to differentiate between fungal pathogens and lack of detection of mucormycosis. Data about BDG performance for other relevant IMI, such as invasive fusariosis (IF) and invasive scedosporiosis/lomentosporiosis (IS) are scarce. The objective of this study was to assess the sensitivity of BDG for the diagnosis of IF and IS through systematic literature review and meta-analysis. Immunosuppressed patients diagnosed with proven or probable IF and IS, with interpretable BDG data were eligible. A total of 73 IF and 27 IS cases were included. The sensitivity of BDG for IF and IS diagnosis was 76.7% and 81.5%, respectively. In comparison, the sensitivity of serum galactomannan for IF was 27%. Importantly, BDG positivity preceded the diagnosis by conventional methods (culture or histopathology) in 73% and 94% of IF and IS cases, respectively. Specificity was not assessed because of lacking data. In conclusion, BDG testing may be useful in patients with suspected IF or IS. Combining BDG and galactomannan testing may also help differentiating between the different types of IMI.

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Section: Resultsmentioning

confidence: 99%