Case Report: Effect of Antigravity Treadmill Training on Muscle Oxidative Capacity, Muscle Endurance, and Walking Function in a Person with Multiple Sclerosis

Willingham, T. Bradley; Melbourn, Jonathan; Moldavskiy, Marina; McCully, Kevin K.; Backus, Deborah

doi:10.7224/1537-2073.2017-035

Cited by 7 publications

(5 citation statements)

References 37 publications

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“…We chose to use accelerometer-based mechanomyography (aMMG) to evaluate muscle endurance [ 13 ]. This approach has been used successfully on limb muscles [ 18 , 19 ] and muscles in the upper back [ 16 ]. Studies of the lower back muscles have reported changes in surface muscle electromyography signals and force development as indices of fatigue/endurance [ 4 , 5 ].…”

Section: Discussionmentioning

confidence: 99%

Muscle-Specific Endurance of the Lower Back Erectors Using Electrical Twitch Mechanomyography

McCully

Moraes

Patel

et al. 2019

JFMK

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Lower back pain is a common symptom potentially associated with skeletal muscle dysfunction. The purpose of this study was to evaluate endurance in the lower back muscles of healthy participants using accelerometer-based mechanomyography. Methods: Young healthy subjects (N = 7) were tested. Surface electrodes and a tri-axial accelerometer were placed over the erector spinae muscle along the T11-L1 Vertebrae. Stimulation was for 3 min each at 2, 4, and 6 Hz, and changes in acceleration were used to calculate an endurance index (EI). Reproducibility of the endurance index measurements was tested on two separate days. Wrist flexor and vastus lateralis muscles were tested for comparison. Near Infrared Spectroscopy (NIRS) was used to measure muscle oxygen levels (O 2 Hb) (N = 5).

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Section: Discussionmentioning

confidence: 99%

Muscle-Specific Endurance of the Lower Back Erectors Using Electrical Twitch Mechanomyography

McCully

Moraes

Patel

et al. 2019

JFMK

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“…We showed that patients with high levels of disability were able to complete GXT in 10 out of 25 occasions (40% success rate) and 50% of our participants achieved 90% of their age-predicted maximal heart rates during GXT, potentially important information needed for planning of future studies among patients with high levels of MS-related disability [26,78,82,84,85,[87][88][89][90][91][92]. We found that our participants with high disability achieved 12.2% greater maximal workload during GXT as a result of training, despite small increases in maximal heart rate (1.8%), maximal respiratory exchange ratio (2.2%), and maximal V O 2 (6.6%).…”

Section: Ability To Perform Gxt and Improvements In Cardiorespiratorymentioning

confidence: 69%

Vigorous cool room treadmill training to improve walking ability in people with multiple sclerosis who use ambulatory assistive devices: a feasibility study

et al. 2020

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Background: Aerobic training has the potential to restore function, stimulate brain repair, and reduce inflammation in people with Multiple Sclerosis (MS). However, disability, fatigue, and heat sensitivity are major barriers to exercise for people with MS. We aimed to determine the feasibility of conducting vigorous harness-supported treadmill training in a room cooled to 16°C (10 weeks; 3times/week) and examine the longer-term effects on markers of function, brain repair, and inflammation among those using ambulatory aids.Methods: Ten participants (9 females) aged 29 to 74 years with an Expanded Disability Status Scale ranging from 6 to 7 underwent training (40 to 65% heart rate reserve) starting at 80% self-selected walking speed. Feasibility of conducting vigorous training was assessed using a checklist, which included attendance rates, number of missed appointments, reasons for not attending, adverse events, safety hazards during training, reasons for dropout, tolerance to training load, subjective reporting of symptom worsening during and after exercise, and physiological responses to exercise. Functional outcomes were assessed before, after, and 3 months after training. Walking ability was measured using Timed 25 Foot Walk test and on an instrumented walkway at both fast and self-selected speeds. Fatigue was measured using fatigue/energy/vitality sub-scale of 36-Item Short-Form (SF-36) Health Survey, Fatigue Severity Scale, modified Fatigue Impact Scale. Aerobic fitness (maximal oxygen consumption) was measured using maximal graded exercise test (GXT). Quality-of-life was measured using SF-36 Health Survey. Serum levels of neurotrophin (brain-derived neurotrophic factor) and cytokine (interleukin-6) were assessed before and after GXT. Results: Eight of the ten participants completed training (attendance rates ≥ 80%). No adverse events were observed. Fast walking speed (cm/s), gait quality (double-support (%)) while walking at self-selected speed, fatigue (modified Fatigue Impact Scale), fitness (maximal workload achieved during GXT), and quality-of-life (physical functioning sub-scale of SF-36) improved significantly after training, and improvements were sustained after 3months. Improvements in fitness (maximal respiratory exchange ratio and maximal oxygen consumption during GXT) were associated with increased brain-derived neurotrophic factor and decreased interleukin-6. Conclusion: Vigorous cool room training is feasible and can potentially improve walking, fatigue, fitness, and quality-of-life among people with moderate to severe MS-related disability.

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“…We showed that patients with high levels of disability were able to complete GXT in 10 out of 25 occasions (40% success rate) and 50% of our participants achieved 90% of their age-predicted maximal heart rates during GXT, potentially important information needed for planning of future studies among patients with high levels of MS-related disability (26,78,85,86,(88)(89)(90)(91)(92)(93)(94). We found that our participants with high disability achieved 12.2% greater maximal workload during GXT as a result of training, despite small increases in maximal heart rate (1.8%), maximal respiratory exchange ratio (2.2%), and maximal VȮ 2 (6.6%).…”

Section: Ability To Perform Gxt and Improvements In Cardiorespiratory Reservementioning

confidence: 69%

Vigorous cool room treadmill training to improve walking ability in people with Multiple Sclerosis who use ambulatory assistive devices: A feasibility study.

Devasahayam

Chaves

Lasisi

et al. 2020

Preprint

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Background: Aerobic training has the potential to restore function, stimulate brain repair, and reduce inflammation in people with Multiple Sclerosis (MS). However, disability, fatigue, and heat sensitivity are major barriers to exercise for people with MS. We aimed to determine the feasibility of conducting vigorous harness-supported treadmill training in a room cooled to 16°C (10 weeks; 3times/week) and examine the longer-term effects on markers of function, brain repair, and inflammation among those using ambulatory aids. Methods: Ten participants (9 females) aged 29 to 74 years with an Expanded Disability Status Scale ranging from 6 to 7 underwent training (40 to 65% heart rate reserve) starting at 80% self-selected walking speed. Feasibility of conducting vigorous training was assessed using a checklist, which included attendance rates, number of missed appointments, reasons for not attending, adverse events, safety hazards during training, reasons for dropout, tolerance to training load, subjective reporting of symptom worsening during and after exercise, and physiological responses to exercise. Functional outcomes were assessed before, after, and 3 months after training. Walking ability was measured using Timed 25 Foot Walk test and on an instrumented walkway at both fast and self-selected speeds. Fatigue was measured using fatigue/energy/vitality sub-scale of 36-Item Short-Form (SF-36) Health Survey, Fatigue Severity Scale, modified Fatigue Impact Scale. Aerobic fitness (maximal oxygen consumption) was measured using maximal graded exercise test (GXT). Quality-of-life was measured using SF-36 Health Survey. Serum levels of neurotrophin (brain-derived neurotrophic factor) and cytokine (interleukin-6) were assessed before and after GXT. Results: Eight of the ten participants completed training (attendance rates >80%). No adverse events were observed. Fast walking speed (cm/s), gait quality (double-support (%)) while walking at self-selected speed, fatigue (modified Fatigue Impact Scale), fitness (maximal workload achieved during GXT), and quality-of-life (physical functioning sub-scale of SF-36) improved significantly after training, and improvements were sustained after 3-months. Improvements in fitness (maximal respiratory exchange ratio and maximal oxygen consumption during GXT) were associated with increased brain-derived neurotrophic factor and decreased interleukin-6. Conclusion: Vigorous cool room training is feasible and can potentially improve walking, fatigue, fitness, and quality-of-life among people with moderate to severe MS-related disability.

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Case Report: Effect of Antigravity Treadmill Training on Muscle Oxidative Capacity, Muscle Endurance, and Walking Function in a Person with Multiple Sclerosis

Abstract: Muscle oxidative capacity and muscle endurance, as well as walking function, improved in a person with MS after training on an antigravity treadmill.

Cited by 7 publications

References 37 publications

Muscle-Specific Endurance of the Lower Back Erectors Using Electrical Twitch Mechanomyography

Muscle-Specific Endurance of the Lower Back Erectors Using Electrical Twitch Mechanomyography

Vigorous cool room treadmill training to improve walking ability in people with multiple sclerosis who use ambulatory assistive devices: a feasibility study

Vigorous cool room treadmill training to improve walking ability in people with Multiple Sclerosis who use ambulatory assistive devices: A feasibility study.

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