Case report Extracardiac rhabdomyomas – presentation of two cases with analysis of AKT/mTOR and ERK1/2 signaling

Iżycka‐Świeszewska, Ewa; Wesołowski, Wojciech; Hermann, Blanka

doi:10.5114/pjp.2015.53016

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…14 It is of great interest that the mTOR pathway is also activated in extracardiac rhabdomyomas. 15 In light of these findings mTOR-Inhibitors seem to be a promising option in the therapy of…”

Section: Discussionmentioning

confidence: 99%

Rhabdomyoma of the tongue base

Vahl

Baumann

Hoffmann

2019

Int J Otorhinolaryngol Head Neck Surg

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<p class="abstract">Extracardiac rhabdomyoma is a very rare condition with potentially multifocal manifestations including the head and neck region. We present a case of an 81-year-old patient who presented as a medical emergency because of ambiguous, progressive throat pain and dysphagia. After diagnostic work up including magnetic resonance (MR) scan and biopsy a rhabdomyoma of the tongue base was diagnosed. The tumor was completely excised by transoral laser microsurgery and the patient’s symptoms vanished. This case report is described in context of the current literature with a discussion of diagnostic steps and treatment options of rhabdomyoma in the head and neck region. Rhabdomyoma is a rare, but nevertheless relevant differential diagnosis of head and neck tumors.</p>

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Section: Discussionmentioning

confidence: 99%

Rhabdomyoma of the tongue base

Vahl

Baumann

Hoffmann

2019

Int J Otorhinolaryngol Head Neck Surg

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Case Report and Review of the Literature of a Rare Entity of a Uterine Fibroid: A Genital Rhabdomyoma

Huesmann

Wiegand

Barth

et al. 2019

International Journal of Gynecological Pathology

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Extracardiac rhabdomyomas are rare benign tumors. According to histopathologic and clinical characteristics, they are divided into 3 subgroups: adult, fetal, and genital rhabdomyomas. Various adult extracardiac rhabdomyomas have been reported in the head and neck region, whereas genital rhabdomyomas are uncommon. Here, we report on a uterine genital rhabdomyoma in a 32-yr-old woman with secondary sterility. After myomectomy, the histopathologic analysis showed a slow cycling tumor with striated muscle differentiation and without any evidence of malignancy. Immunohistochemical staining proved coexpression of actin, caldesmon, and desmin. To the best of our knowledge, this is the first case of a uterine-based genital rhabdomyoma.

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Rhabdomyoma of the Oral Cavity Mimicking Reactive Lesions: A Case Report and Review of the Literature

Mahdavi,

Saebnoori,

Tabatabaie-Zadeh

2023

Ear Nose Throat J

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Extracardiac rhabdomyoma is a tumor that rarely occurs in head and neck region. Adult and fetal types of extracardiac rhabdomyoma are diagnosed only by histopathological examination. In the oral cavity, this lesion usually affects the mouth floor and tongue. Despite the low incidence, adult rhabdomyoma should be considered in the differential diagnosis of oral cavity lesions, and histopathological evaluation might be helpful for the final diagnosis. This study aims to report a rare case of rhabdomyoma mimicking reactive lesions and review the literature. A 34-year-old male was referred to the pathology department with a yellowish sessile lesion in the labial maxillary vestibule. During an excisional biopsy, a mass of unencapsulated soft tissue beneath the vestibular mucosa was observed. The yellowish color in clinical features has led to lipoma as the initial clinical diagnosis. The histological examination exhibited an encapsulated, well-circumscribed benign neoplasm composed of multiple lobules of large polygonal cells with prominent abundant granular eosinophilic cytoplasm. No cellular atypia was observed. Diagnosis of the adult type of rhabdomyoma was made by collective agreement. Rhabdomyoma can be mistaken for other reactive lesions and may resemble their appearance.

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Case report Extracardiac rhabdomyomas – presentation of two cases with analysis of AKT/mTOR and ERK1/2 signaling

Cited by 3 publications

References 12 publications

Rhabdomyoma of the tongue base

Rhabdomyoma of the tongue base

Case Report and Review of the Literature of a Rare Entity of a Uterine Fibroid: A Genital Rhabdomyoma

Rhabdomyoma of the Oral Cavity Mimicking Reactive Lesions: A Case Report and Review of the Literature

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