CASE REPORT: Histological Resolution of Steatohepatitis After Iron Depletion

Riquelme, Arnoldo; Soza, Alejandro; Nazal, Leyla; Martínez, Gabriel García; Kolbach, Marianne; Patillo, Alejandro; Arellano, Juan; Duarte, Ignacio; Martínez, Jorge; Molgó, Monserrat; Arrese, Marco

doi:10.1023/b:ddas.0000034564.68307.39

Cited by 21 publications

(16 citation statements)

References 23 publications

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“…Consistent with our result, it has recently been reported that phlebotomy leads to significant reduction in serum transaminase activities in patients with NAFLD [23] or NASH [24]. Facchini et al have shown improvement in liver enzymes levels in 17 NAFLD patients treated with serial phlebotomy for iron reduction [23].…”

Section: Discussionsupporting

confidence: 92%

Effect of iron reduction by phlebotomy in Japanese patients with nonalcoholic steatohepatitis: A pilot study☆

Sumida

Kanemasa

Fukumoto

et al. 2006

Hepatology Research

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Section: Discussionsupporting

confidence: 92%

Effect of iron reduction by phlebotomy in Japanese patients with nonalcoholic steatohepatitis: A pilot study☆

Sumida

Kanemasa

Fukumoto

et al. 2006

Hepatology Research

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“…26 On the other hand, Riquelme et al 27 recently reported that patients with NASH who underwent phlebotomy showed histopathological improvement. Based on the above studies, although no statistical significance of steatosis in relation to response to the therapy was noted in our analysis, further studies are necessary to examine the role of steatosis in hepatocytes in the failure of ALT normalization.…”

Section: Discussionmentioning

confidence: 99%

Determinants of serum ALT normalization after phlebotomy in patients with chronic hepatitis C infection

et al. 2005

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“…Sumida et al [112] also reported that phlebotomy decreased serum transaminase activities in Japanese patients with biopsy-proven NASH. Riquelme et al [113] reported that a 52-year-old nonobese woman with biopsy-proven NASH obtained not only improvement in transaminase activities but also complete resolution of fatty infiltration and inflammatory changes in liver histology after iron depletion therapy (long-term phlebotomy with a low-iron diet). According to a case-control study [114], iron depletion produced a significantly larger decrease in ALT activities compared with nutritional counseling alone, independent of changes in BMI and the presence of the metabolic syndrome.…”

Section: Metformin Cq: Are Biguanides Effective For Patients With Nafmentioning

confidence: 99%

Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

et al. 2015

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Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease in industrialized countries worldwide, and has become a serious public health issue not only in Western countries but also in many Asian countries including Japan. Within the wide spectrum of NAFLD, nonalcoholic steatohepatitis (NASH) is a progressive form of disease, which often develops into liver cirrhosis and increases the risk of hepatocellular carcinoma. In turn, a large proportion of NAFLD/NASH is the liver manifestation of metabolic syndrome, suggesting that NAFLD/NASH plays a key role in the pathogenesis of systemic atherosclerotic diseases. Currently, a definite diagnosis of NASH requires liver biopsy, though various noninvasive measures are under development. The mainstays of prevention and treatment of NAFLD/NASH include dietary restriction and exercise; however, pharmacological approaches are often necessary.Currently, vitamin E and thiazolidinedione derivatives are the most evidence-based therapeutic options, although the clinical evidence for long-term efficacy and safety is limited. This practice guideline for NAFLD/NASH, established by the Japanese Society of Gastroenterology in cooperation with The Japan Society of Hepatology, covers lines of clinical evidence reported internationally in the period starting from 1983 to January 2012, and each clinical question was evaluated using the GRADE system. Based on the primary release of the full version in Japanese, this English summary provides the core essentials of this clinical practice guideline comprising the definition, diagnosis, and current therapeutic recommendations for NAFLD/NASH in Japan.

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CASE REPORT: Histological Resolution of Steatohepatitis After Iron Depletion

Cited by 21 publications

References 23 publications

Effect of iron reduction by phlebotomy in Japanese patients with nonalcoholic steatohepatitis: A pilot study☆

Effect of iron reduction by phlebotomy in Japanese patients with nonalcoholic steatohepatitis: A pilot study☆

Determinants of serum ALT normalization after phlebotomy in patients with chronic hepatitis C infection

Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

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