Case Report: Improvement of Long Lasting Hyperpigmentation by Aqueous Human Placenta Extract (Reju Growth Factor, RGF&amp;amp;#174) Treatment

Phonchai, Ruchee; Ubonsaen, Bunchob; Brameld, Supaluk; Naigovit, Pimjai

doi:10.4236/jcdsa.2019.92011

JCDSA

2019

DOI: 10.4236/jcdsa.2019.92011

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Case Report: Improvement of Long Lasting Hyperpigmentation by Aqueous Human Placenta Extract (Reju Growth Factor, RGF&#174) Treatment

Ruchee Phonchai¹,

Bunchob Ubonsaen²,

Supaluk Brameld³

et al.

Abstract: Hyperpigmentation is a common skin problem in a woman. Prolonging topical use of skin whitening may cause hyperpigmentation such as ochronosis whose condition is a challenge for treatment. An aqueous human placenta extract (RGF®) contains bioactive therapeutic molecules. There is evidence of human placenta extract showing that melanin synthesis is inhibited by placenta extract in melanocytes. We first reported the case of the hyperpigmentation improvement following face skin mesotherapy human placenta extract … Show more

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2023

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Design and initial characterization of fabricated composite scaffold dHPCTM-HPE (decellularized human placental connective tissue matrix - human placental extract)

Abhaya,

Misra

et al. 2023

Preprint

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Purpose The placenta, a prominent source of scaffolding material, has primarily been utilized in wound care. Enriched with numerous growth factors and extracellular matrix components, it holds the potential to create an exceptionally favorable environment for wound healing. The purpose of this study is to develop a combination product from placenta and evaluate the impact of processing method over bioactive molecules. Methods We developed a decellularized human placental connective tissue matrix (dHPCTM) and placental extract (HPE). These were combined in a 1:1 ratio to create a composite product known as dHPCTM-HPE. The fabricated products were obtained through processes involving homogenization, mechanical and chemical treatments, and freeze-drying. To ascertain the retention of structural and bioactive molecules within these products, we conducted quantification tests for amino acids, collagen, glycosamninoglycans, histological evaluation, porosity, and swelling ratio. Results The combined product, dHPCTM-HPE, exhibited superior biochemical and mechanical properties when compared to dHPCTM or HPE alone. Conclusion This combination shows promise for the treatment of chronic and deeper wounds where a single intervention is less likely to yield optimal results.

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Design and initial characterization of fabricated composite scaffold dHPCTM-HPE (decellularized human placental connective tissue matrix - human placental extract)

Abhaya,

Misra

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

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Case Report: Improvement of Long Lasting Hyperpigmentation by Aqueous Human Placenta Extract (Reju Growth Factor, RGF&#174) Treatment

Cited by 1 publication

References 15 publications

Design and initial characterization of fabricated composite scaffold dHPCTM-HPE (decellularized human placental connective tissue matrix - human placental extract)

Design and initial characterization of fabricated composite scaffold dHPCTM-HPE (decellularized human placental connective tissue matrix - human placental extract)

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