Case report: Intraneural perineurioma of the sciatic nerve in an adolescent – strategies for revealing the diagnosis

Dahlin, Lars B.; Nennesmo, Inger; Besjakov, Jack; Ferencz, Istvan; Andersson, Gustav; Backman, Christer

doi:10.1002/ccr3.630

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…The full text of the remaining 57 articles was reviewed and 35 articles were then excluded. Therefore, 22 articles met the inclusion criteria [5,9,[12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31], comprising 74 cases of PN (Table 1).…”

Section: Results Of the Systematic Reviewmentioning

confidence: 99%

Modern treatment of perineuriomas: a case-series and systematic review

et al. 2020

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Background: Perineuriomas are rare benign peripheral nerve sheath tumours of perineurial cell origin and can be classified into intraneural and extraneural perineuriomas. They most commonly present a mononeuropathy of gradual onset and slow progression, resulting in progressive neurological deficits like hypoesthesia or motor weakness. Therapy is still variable. Aim of the study was to compare our surgical treatment and our follow-up regime including high-resolution nerve sonography with the current literature to evaluate best treatment of perineuriomas. Methods: Retrospective analysis of our dataset "peripheral nerve lesion" to identify patients suffering from perineuriomas between 01.01.2012 until 31.12.2018. Surgical treatment and the follow-up examination of three patients were described. Additionally, a systematic review including PubMed, the Cochrane Collaboration Library, Scopus and Google Scholar was performed for literature published between January 1, 1990 and October 31, 2019 independently by 2 authors. Results: In the first case, the left ulnar nerve was affected. In the second case, the left peroneal nerve and in the third case the right median nerve was affected. High-resolution nerve sonography was performed in each case. All patients underwent interfascicular neurolysis combined with a targeted fascicular biopsy under electrophysiological monitoring. Neurological deficits improved subsidized by rehabilitation. Surgical therapy and the neurological outcome were compared with literature. Systematic review revealed 22 articles, which met the inclusion criteria. Therefore, demographics, surgical treatment and neurological outcome of 77 patients were analysed. Conclusions: Perineuriomas are rare benign nerve sheath tumours with a slow progression, sometimes difficult to diagnose. Decompression and neurolysis may improve neurological deficits. High resolution nerve sonography might serve as a helpful additional diagnostic tool in this process.

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Section: Results Of the Systematic Reviewmentioning

confidence: 99%

Modern treatment of perineuriomas: a case-series and systematic review

et al. 2020

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“…IPN have been described in case reports involving single and multiple peripheral nerves including sciatic, femoral, peroneal, tibial, brachial plexus, ulnar, median, radial, facial, mandibular dental, oculomotor, tongue, C8/T1, and jugulocarotid region of the neck and laryngeal. 3 , 4 , 5 , 6 , 7 Until recently, the diagnosis of intraneural perineuriomas has been complicated by the inability to differentiate between lesions of Schwann cells (forming real onion bulb whorls) and perineural cells (forming pseudo-onion bulbs). This has contributed to misdiagnosis and the use of multiple different names for intraneural perineurioma in the literature including localized hypertrophic mononeuropathy (LHM), interstitial hypertrophic neuropathy, pseudo-onion bulb neuropathy, intraneural neurofibroma, hypertrophic neurofibrosis, and hypertrophic interstitial neuritis.…”

Section: Introductionmentioning

confidence: 99%