Case report: Malignant fibrous histiocytoma complicating chronic osteomyelitis

Kennedy, Cheika; Stoker, Dennis

doi:10.1016/s0009-9260(05)80611-7

Cited by 14 publications

(8 citation statements)

References 16 publications

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“…10 MFH complicating chronic osteomyelitis is generally localized at the level of the bone tissue and presents clinically with raising of the involved bone segment, pain and spontaneous fracture. [5][6][7][8] In the case we report the neoplasm was primitively localized at the dermal and subcutaneous level and the first sign was the appearance of a rapidly growing vegetative mass.…”

Section: Discussionmentioning

confidence: 99%

Malignant fibrous histiocytoma arising on chronic osteomyelitis

Foti¹,

Giannelli²,

Berloco³

et al. 2002

Acad Dermatol Venereol

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We present a case of a primary malignant fibrous histiocytoma of the skin (MFH) arising on chronic osteomyelitis in a 67-year-old woman. Although this condition seems to be a predisposing factor for the onset of the malignancy, MFH complicating chronic osteomyelitis is generally localized at the level of the bone tissue. In the case we report the neoplasm was primitively localized at the dermal and subcutaneous level and presented as a rapidly growing mass.

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Section: Discussionmentioning

confidence: 99%

Malignant fibrous histiocytoma arising on chronic osteomyelitis

Foti¹,

Giannelli²,

Berloco³

et al. 2002

Acad Dermatol Venereol

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“…Discussion SCC is the most common type of malignant tumour that evolves at the site of chronic osteomyelitis [3,8,11]. Fibrosarcoma [1,9,12,13], myeloma [7], lymphoma [7,12], plasmacytoma [15] angiosarcoma [2,4,14,16], rhabdomyosarcoma [7], and malignant fibrous histiocytoma [4,6,10] also have been reported. The latency period is between 20 and 50 years [7,8,20].…”

Section: Resultsmentioning

confidence: 99%

Squamous cell carcinoma arising in chronic osteomyelitis

Sağlık

Arıkan

Altay

et al. 2001

International Orthopaedics (SICOT)

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Squamous cell carcinoma (SCC) is a rare but well-documented complication of chronic osteomyelitis. Between February 1991 and March 1999, 13 cases (12 men and one woman) of SCC arising in chronic osteomyelitis were diagnosed and treated in our clinic. Mean age was 56.5 (38-70) years. Twelve patients underwent amputation and one underwent limb salvage. Average follow-up was 56 (24-121) months. Among the 13 patients two died of the disease. Treatment of choice for these tumours has been amputation.Resume Carcinome cellulaire squameux est une complication d'ostéomyélite, peu fréquente, mais bien connue. Entre le février 91-mars 99, dans notre clinique, nous ont constate 13 malades (12 hommes et 1 femme) a qui nous ont vu la maladie développe a la base d'ostéomyélite chronique. L'age moyen était 56.5. (38-70) 12 malades ont subi une amputation et dans l'autre l'extrémité a été gardée. La surveillance a duré à peu près 56 (24-121) mois. Parmi ces 13 malades seulement deux sont morts. Pour ces tumeurs on peut dire que l'amputation est la méthode la plus efficace.

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“…Although considered as a rare complication of chronic osteomyelitis, carcinomas and sarcomas may occur in chronic draining sinuses of osteomyelitis [4][5][6][7]12], a well-known phenomena since over a century. In the current study, we describe 6 cases of well-diVerentiated squamous cell carcinoma, which developed in long-standing chronic osteomyelitis.…”

Section: Discussionmentioning

confidence: 99%

“…In the majority of the cases, this is a squamous cell carcinoma, and other tumors that may be found are for example myeloma, sarcoma, and lymphoma [3][4][5][6][7]. The incidence of malignant transformation in chronic osteomyelitis is reported between 0.2 and 1.7% of cases of chronic osteomyelitis [8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Malignancy transformation of chronic osteomyelitis: description of 6 cases of Marjolin’s ulcers

Steinrücken¹,

Osterheld

Trampuž³

et al. 2011

Eur J Orthop Surg Traumatol

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Background Marjolin's ulcer describes any malignant transformation of a chronic inXammatory lesion. In the majority of cases, a squamous cell carcinoma is diagnosed. Malignant transformation occurs usually after a long period of latency of chronic infection; it takes approximately 35 years on average. There are no typical clinical presentations, but several indirect signs may suggest the malignant transformation, such as increased or changed discharge, pathologic fracture, a slow-growing exophytic mass, or other suggestive signs of malignant transformation, which should prompt to biopsy for histological exam. The diagnosis of chronic osteomyelitis should not prevent to search for carcinoma. Case description We present six patients with chronic osteomyelitis that developed well-diVerentiated squamous cell carcinoma. All patients were older than 50 years (mean 60 years, range 52-77 years). Five Marjolin's ulcers were located on the lower limb and one on the arm. The average time of the chronic discharging osteomyelitis before diagnosis of carcinoma ranged between 12 and 40 years. All patients were treated by amputation of the aVected limb. None had metastasis, and one patient developed local recurrence and received palliative treatment. Clinical relevance Our study emphasizes that Marjolin's ulcer should be considered as a rare but signiWcant longterm complication of chronic osteomyelitis. The Wnding of microorganisms should not prevent from further diagnostic procedures by histopathological examination so that the correct surgical treatment can be performed.

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Case report: Malignant fibrous histiocytoma complicating chronic osteomyelitis

Cited by 14 publications

References 16 publications

Malignant fibrous histiocytoma arising on chronic osteomyelitis

Malignant fibrous histiocytoma arising on chronic osteomyelitis

Squamous cell carcinoma arising in chronic osteomyelitis

Malignancy transformation of chronic osteomyelitis: description of 6 cases of Marjolin’s ulcers

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