Case Report: Management Approach and Use of Extracorporeal Membrane Oxygenation for Diffuse Alveolar Hemorrhage After Pediatric Hematopoietic Cell Transplant

Fan, Kimberly; Hurley, Caitlin; McNeil, Michael J.; Agulnik, Asya; Federico, Sara M.; Qudeimat, Amr; Saini, Arun; McArthur, Jennifer; Morrison, R. Ray; Sandhu, Hitesh; Shah, Samir; Ghafoor, Saad

doi:10.3389/fped.2020.587601

Cited by 10 publications

(9 citation statements)

References 26 publications

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“…12 Fi nally, extra cor po real mem brane oxy gen a tion has been rarely employed. 13 DAH is con sis tently diag nosed, while its eti ol ogy and opti mal treat ment are unknown, though local ther a pies may offer the greatest ben e fit, and highdose ste roid use has waned.…”

Section: Diffuse Alve O Lar Hem or Rhagementioning

confidence: 99%

Noninfectious lung complications of hematopoietic cell transplantation

Williams

2021

Hematology

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Noninfectious lung diseases contribute to nonrelapse mortality. They constitute a spectrum of diseases that can affect the parenchyma, airways, or vascular pulmonary components and specifically exclude cardiac and renal causes. The differential diagnoses of these entities differ as a function of time after hematopoietic cell transplantation. Specific diagnosis, prognosis, and optimal treatment remain challenging, although progress has been made in recent decades.

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Section: Diffuse Alve O Lar Hem or Rhagementioning

confidence: 99%

Noninfectious lung complications of hematopoietic cell transplantation

Williams

2021

Hematology

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“…Sixty-four manuscripts met search criteria and 24 were included as primary reports of pediatric HCT patients who underwent ECLS. These 24 reports included 11 single case reports (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27), four single institution case series (28)(29)(30)(31), two multi-institution case series (32,33), and seven registry reports from Extracorporeal Life Support Organization (ELSO), Pediatric Heath Information System (PHIS), and Virtual Pediatric Systems (VPS) (14,15,(34)(35)(36)(37)(38). As patients included in these case reports, series, and registries are variably deidentified, we cannot exclude the possibility of patient overlap in these multiple manuscript formats.…”

Section: Resultsmentioning

confidence: 99%

Candidacy for Extracorporeal Life Support in Children After Hematopoietic Cell Transplantation: A Position Paper From the Pediatric Acute Lung Injury and Sepsis Investigators Network’s Hematopoietic Cell Transplant and Cancer Immunotherapy Subgroup

Zinter

McArthur

Duncan

et al. 2021

Pediatric Critical Care Medicine

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The last decade has seen improved outcomes for children requiring extracorporeal life support as well as for children undergoing hematopoietic cell transplantation. Thus, given the historically poor survival of hematopoietic cell transplantation patients using extracorporeal life support, the Pediatric Acute Lung Injury and Sepsis Investigators' hematopoietic cell transplantation and cancer immunotherapy subgroup aimed to characterize the utility of extracorporeal life support in facilitating recovery from critical cardiorespiratory illnesses in pediatric hematopoietic cell transplantation patients. DATA SOURCES:All available published data were identified using a set of PubMed search terms for pediatric extracorporeal life support and hematopoietic cell transplantation. STUDY SELECTION:All articles that provided original reports of pediatric hematopoietic cell transplantation patients who underwent extracorporeal life support were included. Sixty-four manuscripts met search criteria. Twenty-four were included as primary reports of pediatric hematopoietic cell transplantation patients who underwent extracorporeal life support (11 were single case reports, four single institution case series, two multi-institution case series, and seven registry reports from Extracorporeal Life Support Organization, Pediatric Heath Information System, and Virtual Pediatric Systems). DATA EXTRACTION:All 24 articles were reviewed by first and last authors and a spread sheet was constructed including sample size, potential biases, and conclusions.DATA SYNTHESIS: Discussions regarding incorporation of available evidence into our clinical practice were held at biannual meetings, as well as through email and virtual meetings. An expert consensus was determined through these discussions and confirmed through a modified Delphi process. CONCLUSIONS:Extracorporeal life support in hematopoietic cell transplantation patients is being used with increasing frequency and potentially improving survival.

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“…7,9 There are also case reports that address more specific cases where ECMO was successful in saving children with neuroblastoma or hematologic malignancy from posttransplant complications. [10][11][12] It is also likely that the "ECMO failures" in similar patients may not be reported as readily in the literature. Earlier this year, the hematopoietic cell transplantation-cancer immunotherapy subgroup of The Pediatric Acute Lung Injury and Sepsis Investigators released a framework to guide the clinical team when considering ECMO support for patients post-HSCT.…”

Section: Discussionmentioning

confidence: 99%

The Use of Extracorporeal Membrane Oxygenation as a Bridge to Bone Marrow Transplantation in a Patient With High-risk Acute Myeloid Leukemia

Nader¹,

Bonde²,

Massaro³

et al. 2022

Journal of Pediatric Hematology/Oncology

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An 18-year-old girl with high-risk acute myeloid leukemia developed Streptococcus mitis septic shock and multiorgan dysfunction syndrome, including biventricular failure. Due to the anticipated reversibility of her cardiogenic shock, her young age, and her favorable survival chance after an allogeneic hematopoietic stem cell transplant, she was placed on full circulatory support with venoarterial extracorporeal membrane oxygenation as a bridge to her successful hematopoietic stem cell transplantation 2 months later. This highlights the importance of prognostication in patient selection for extracorporeal life support. A multidisciplinary approach is essential to each case until more definite initiation criteria, risk stratification, and treatment protocols are established.

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Case Report: Management Approach and Use of Extracorporeal Membrane Oxygenation for Diffuse Alveolar Hemorrhage After Pediatric Hematopoietic Cell Transplant

Cited by 10 publications

References 26 publications

Noninfectious lung complications of hematopoietic cell transplantation

Noninfectious lung complications of hematopoietic cell transplantation

Candidacy for Extracorporeal Life Support in Children After Hematopoietic Cell Transplantation: A Position Paper From the Pediatric Acute Lung Injury and Sepsis Investigators Network’s Hematopoietic Cell Transplant and Cancer Immunotherapy Subgroup

The Use of Extracorporeal Membrane Oxygenation as a Bridge to Bone Marrow Transplantation in a Patient With High-risk Acute Myeloid Leukemia

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