Case Report: Multiple Strokes and Digital Ischemia in a Young COVID-19 Patient

Harsh, Shah; Iyer, Aditya; Zaghlol, Raja; Raparla, Sandeep

doi:10.4269/ajtmh.20-1101

Cited by 9 publications

(6 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cerebrovascular diseases 2 (28.6) (Xiong et al, 2020;Tiwari et al, 2021) 3 (13.6) (Asif and O' Mahony, 2020;Gulko et al, 2020;Dakay et al, 2021) 3 (15.8) (Cavalcanti et al, 2020;de Sousa et al, 2020;Dakay et al, 2021) 19 (31.7) (Al Saiegh et al, 2020;Cavalcanti et al, 2020;Cezar-Junior et al, 2020;Chia et al, 2020;Diaz-Segarra et al, 2020;Fara et al, 2020;Kantonen et al, 2020;Oxley et al, 2020;Pisano et al, 2020;Trifan et al, 2020a,b;Vu et al, 2020;Wang et al, 2020;Al-Mufti et al, 2021;Sabayan et al, 2021;Shah et al, 2021) 31 (43.1) (Agarwal et al, 2020;Anzalone et al, 2020;Cavalcanti et al, 2020;de Almeida Lima et al, 2020;Fabbri et al, 2021;Gupta et al, 2020;Heman-Ackah et al, 2020;Lapergue et al, 2020;Nicholson et al, 2020;Oxley et al, 2020;Patel et al, 2020;…”

Section: Age-associated Neurological Complications Of Covid-19unclassified

Age-Associated Neurological Complications of COVID-19: A Systematic Review and Meta-Analysis

Sullivan

Fischer

2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

The outbreak of the novel and highly infectious severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in hundreds of millions of infections and millions of deaths globally. Infected individuals that progress to coronavirus disease-19 (COVID-19) experience upper and lower respiratory complications that range in severity and may lead to wide-spread inflammation and generalized hypoxia or hypoxemia that impacts multiple organ systems, including the central and peripheral nervous systems. Since the SARS-CoV-2 outbreak, multiple reports continue to emerge that detail neurological symptoms, ranging from relatively mild (e.g., impaired taste and/or smell) to severe (e.g., stroke), suggesting SARS-CoV-2 may be neurotropic and/or contribute to nervous system injury through direct and/or indirect mechanisms. To gain insight into the types of neurological complications associated with SARS-CoV-2 infection and their possible relationship with age, sex, COVID-19 severity, and comorbidities, we performed a systematic review of case reports and series published in 2020 – April 4, 2021 of infected patients with neurological manifestations. Meta-analyses were conducted using individual patient data from reports where these data could be extracted. Here, we report neurological injury occurs across the lifespan in the context of infection, with and without known comorbidities, and with all disease severities, including asymptomatic patients. Older individuals, however, are more susceptible to developing life-threatening COVID-19 and cerebrovascular disease (CVD), such as stroke. A mild but inverse correlation with age was seen with CNS inflammatory diseases, such as encephalitis, as well as taste and/or smell disorders. When reported, increased age was also associated with comorbid cardiovascular risk factors, including hypertension, diabetes mellitus, and lipid disorders, but not with obesity. Obesity did correlate with development of critical COVID-19. Discussion into potential pathophysiological mechanisms by which neurological symptoms arise and long-term consequences of infection to the nervous system is also provided.

show abstract

Section: Age-associated Neurological Complications Of Covid-19unclassified

Age-Associated Neurological Complications of COVID-19: A Systematic Review and Meta-Analysis

Sullivan

Fischer

2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“… 12 , 13 Despite the paucity of large scale randomised controlled evidence evaluating patient-centred outcomes, awake prone positioning generated great interest in the clinical and scientific communities, and it has been incorporated into clinical guidelines 14 and expert consensus statements. 15 , 16 Awake prone positioning has been identified as a research priority by the Surviving Sepsis Research Committee. 17 …”

Section: Introductionmentioning

confidence: 99%

Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial

Ehrmann

Ibarra‐Estrada

et al. 2021

The Lancet Respiratory Medicine

308

375

View full text Add to dashboard Cite

“…Digital ischemia was observed in 2 patients in the intensive care unit, and one of these patients was discharged to the acute care rehabilitation center while the other had mortality, and concurrent venous thrombosis was also demonstrated in these two cases [15]. In another case report, a 34-year-old female patient reported stroke and brachial artery thrombosis at in same time [16]. Considering all these, it should be kept in mind that thrombosis may be seen in other organs concurrently because of coagulopathy.…”

Section: Discussionmentioning

confidence: 97%

Radial arterial thrombosis in COVID-19: A case report

Durmuş

CICEK

EYUPLER

et al. 2022

Marmara Medical Journal

View full text Add to dashboard Cite

Thrombosis due to hypercoagulable state is an important cause of morbidity and mortality in coronavirus disease 2019 (COVID-19). . Increased D-dimer levels are an important marker of the presence and risk of thrombosis. In this report, we present that a 59-yearold male patient developed thrombosis in the distal radial arteries despite normal D-dimer level. The patient was treated with enoxaparin, iloprost infusion, and cilostazol. This

show abstract

Case Report: Multiple Strokes and Digital Ischemia in a Young COVID-19 Patient

Cited by 9 publications

References 10 publications

Age-Associated Neurological Complications of COVID-19: A Systematic Review and Meta-Analysis

Age-Associated Neurological Complications of COVID-19: A Systematic Review and Meta-Analysis

Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial

Radial arterial thrombosis in COVID-19: A case report

Contact Info

Product

Resources

About