Case report: Nocardia gipuzkoensis infection in an immunocompetent patient diagnosed by metagenomic next-generation sequencing and whole genome sequencing

Liu, Chengxin; Yang, Juhua; Huang, Huiting; Zhan, Shaofeng; Xia, Xintian

doi:10.3389/fimmu.2022.1053914

Cited by 6 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although polymerase chain reaction increases the diagnostic reliability, it is difficult to directly identify uncommon pathogens [ 14 , 15 ]. mNGS presents as a culture-free, unbiased, and time-efficient method for the identification of a broad spectrum of pathogens, showcasing an adjunctive tool in clinical diagnosis, particularly for infrequent pathogens such as A algerae infection [ 16 , 17–18 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Anncaliia algerae in Ascites in an Immunosuppressed Patient, China

Wang,

Li,

et al. 2024

Open Forum Infectious Diseases

View full text Add to dashboard Cite

Anncaliia algerae, a microsporidium, has risen to prominence as an opportunistic pathogen, particularly afflicting immunocompromised individuals grappling with conditions such as rheumatoid arthritis, organ transplantation, and hematologic malignancy. Surprisingly, despite its recognized impact, the identification of A. algerae in ascitic fluid has not hitherto been documented. Worthwhile, we pinpointed A. algerae as the probable instigator of ascitic accumulation in a patient with a history of acute myeloid leukemia and extended periods of immunosuppressive therapy. For the patient we described, there were no signs of A. algerae-related infections such as myositis, vocal cord involvement, or disseminated infection. The presence of A.algerae was finally identified by next-generation metagenomic sequencing analysis of the ascitic fluid. The clinical presentation, characterized by elevated C-reactive protein (CRP) levels (110.7 mg/L), diminished platelet count (48 ×109/L), abdominal distension secondary to ascitic fluid accumulation, and lower limb pain, showed marked improvement following a 4-day sulfamethoxazole/trimethoprim (SMZ/TMP) and albendazole regimen. Despite this promising response, the patient tragically succumbed to aspiration of vomitus. This case underscored the importance of considering rarer organisms such as A. algeare infection, in immunocompromised patients presenting with unexplained ascites accumulation. It highlighted the potential effectiveness of SMZ/TMP and albendazole in managing such cases. Further research is warranted to elucidate optimal management strategies and improve outcomes in similar clinical scenarios.

show abstract

Section: Discussionmentioning

confidence: 99%

Identification of Anncaliia algerae in Ascites in an Immunosuppressed Patient, China

Wang,

Li,

et al. 2024

Open Forum Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…Nocardia genus contains a great number of rare opportunistic bacteria that mainly causing pulmonary infections. 3,8,11,12 For extra-pulmonary infections, the central nervous system (CNS) is the most frequent site that exhibits headache, seizures, mental status change, aphasia, and hemiparesis in patients. 13 Nocardial cerebral abscesses account for about 1-2% of all brain abscesses.…”

Section: Discussionmentioning

confidence: 99%

“…As we all know, the cases infected by N. gipuzkoensis has solely been reported in patients with bronchiectasis. 8,9 We now described a rare case of cerebral abscess infected by N. gipuzkoensis in an elderly female patient. And the process of treatment was also shared (Figure 1).…”

Section: Introductionmentioning

confidence: 96%

Cerebral Abscess Infected by Nocardia gipuzkoensis

Li,

Feng,

et al. 2023

IDR

View full text Add to dashboard Cite

Nocardia gipuzkoensis is a novel species that solely identified in patients with pulmonary infections by far. Growing evidence showed the excellent performance of metagenomics next-generation sequencing (mNGS) on pathogenic identification, especially for new species. Here, we described the first case of an elderly female patient suddenly suffering from neurological disorders owing to N. gipuzkoensis infection. And linezolid could effectively treat N. gipuzkoensis infection. Patients and Methods:The results of imaging, laboratory cultures, and mNGS, as well as therapeutic process are shared. Results: An elderly female patient suddenly suffered from neurological disorders with dysphasia and right limb trembles under no obvious causes. Subsequently, she was diagnosed as intracranial space-occupying lesions by magnetic resonance imaging (MRI). The isolate from brain secretion was further identified as N. gipuzkoensis through mNGS. The targeted therapy with linezolid according to the antimicrobial susceptibility was used to treat cerebral abscess induced by N. gipuzkoensis. During the follow-up, no relapse was observed for the patient after surgery for 104 days. Conclusion: Cerebral abscess induced by N. gipuzkoensis is rare disorder with high mortality. mNGS has been identified as a promising tool in pathogen diagnosis for timely therapy. Linezolid as one of the antimicrobial drugs could effectively treat N. gipuzkoensis infection and prevent adverse outcomes.

show abstract

WITHDRAWN: A successful management of concurrent infection with cranial Nocardia gipuzkoensis and pulmonary Klebsiella pneumoniae: A case report

Fang,

Li,

Wang

et al. 2024

IDCases

View full text Add to dashboard Cite

Case report: Nocardia gipuzkoensis infection in an immunocompetent patient diagnosed by metagenomic next-generation sequencing and whole genome sequencing

Cited by 6 publications

References 18 publications

Identification of Anncaliia algerae in Ascites in an Immunosuppressed Patient, China

Identification of Anncaliia algerae in Ascites in an Immunosuppressed Patient, China

Cerebral Abscess Infected by Nocardia gipuzkoensis

WITHDRAWN: A successful management of concurrent infection with cranial Nocardia gipuzkoensis and pulmonary Klebsiella pneumoniae: A case report

Contact Info

Product

Resources

About