Case report of a p16<sup>INK4A</sup>-positive branchial cleft cyst

McLean, Tracy; Iseli, Claire; Amott, Deborah; Taylor, Michael

doi:10.1017/s0022215114003223

Cited by 4 publications

(1 citation statement)

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“…Soh suggested that most cases of branchiogenic carcinomas reported in the literature may have been secondary metastatic lesions from an occult tonsillar carcinoma [ 11 ]. A case report by McLean presented a patient with concurrent oropharyngeal squamous cell carcinoma and branchial cleft cyst that were positive for P16 and HPV DNA [ 35 ]. Lack of evidence of carcinogenic change of the normal epithelium and an identifiable normal lymphoepithelial lining of a cystic space would fail to prove that the tumor originated from the epithelium, and fail to differentiate it from a central necrotic metastatic lymph node [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Controversy Surrounding the Differential Diagnosis of Branchiogenic Carcinoma

Karatzanis

Mylopotamitaki

Lagoudaki

et al. 2022

Case Reports in Otolaryngology

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Clinical evaluation, di erential diagnosis, and management of a neck mass constitute commonly encountered problems for the head and neck surgeon. An asymptomatic neck mass in adults may be the only clinical sign of head and neck cancer. A 50-year-old female patient presented with a painless, slowly enlarging, left lateral neck lump. Ultrasonography described a possible lymph node with cystic degeneration, and ne needle aspiration biopsy only detected atypical cells of squamous epithelium. An open biopsy under general anesthesia was performed. Histopathological ndings suggested the diagnosis of lymph node in ltration by squamous cell carcinoma of an unknown primary site, but di erential diagnosis also included branchiogenic carcinoma arising in a branchial cleft cyst. A diagnostic algorithm for metastatic squamous cell carcinoma of an unknown primary site was followed, including positron emission tomography with computed tomography.e patient underwent panendoscopy and bilateral tonsillectomy, and an ipsilateral p16 positive tonsillar squamous cell carcinoma was detected. Further appropriate management followed. e existence of true branchiogenic carcinoma is controversial. When such a diagnosis is contemplated, every e ort should be made to detect a possible primary site. Branchiogenic carcinoma, if exists at all, remains a diagnosis of exclusion.

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Section: Discussionmentioning

confidence: 99%