Case Report of a Patient With Iliac Occlusive Disease Due to Pseudoxantoma Elasticum and Review of the Bibliography

Siskos, Dimitrios; Giannakakis, Sotirios; Sotirios, Makris; Pirgakis, Konstantinos M.; Psyllas, Anastasios; Maltezos, Chrisostomos

doi:10.1016/j.avsg.2011.07.013

Cited by 7 publications

(2 citation statements)

References 10 publications

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“…The low ABI in our study was preferentially associated with calcification of the femoral segment, suggesting that the drop in peripheral pressure is linked to the development of an arterial obstruction in the proximal arterial segments rather than calcification in the distal arteries. This finding is in accordance with the fact that ischemia requiring surgery often occurs in PXE patients suffering from proximal lesions [43] , [44] . Although the pressure drop below a proximal stenosis can be the most probable explanation to the low ABI, changes in arterial stiffness and compliance, and arterial wave reflection should be considered, but were not measured in the present study.…”

Section: Discussionsupporting

confidence: 89%

The Contribution of Arterial Calcification to Peripheral Arterial Disease in Pseudoxanthoma Elasticum

et al. 2014

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Background and aimsThe contribution of arterial calcification (AC) in peripheral arterial disease (PAD) and arterial wall compressibility is a matter of debate. Pseudoxanthoma elasticum (PXE), an inherited metabolic disease due to ABCC6 gene mutations, combines elastic fiber fragmentation and calcification in various soft tissues including the arterial wall. Since AC is associated with PAD, a frequent complication of PXE, we sought to determine the role of AC in PAD and arterial wall compressibility in this group of patients.Methods and ResultsArterial compressibility and patency were determined by ankle-brachial pressure index (ABI) in a cohort of 71 PXE patients (mean age 48±SD 14 yrs, 45 women) and compared to 30 controls without PAD. Lower limb arterial calcification (LLAC) was determined by non-contrast enhanced helicoidal CT-scan. A calcification score (Ca-score) was computed for the femoral, popliteal and sub-popliteal artery segments of both legs. Forty patients with PXE had an ABI<0.90 and none had an ABI>1.40. LLAC increased with age, significantly more in PXE subjects than controls. A negative association was found between LLAC and ABI (r = −0.363, p = 0.002). The LLAC was independently associated with PXE and age, and ABI was not linked to cardiovascular risk factors.ConclusionsThe presence of AC was associated with PAD and PXE without affecting arterial compressibility. PAD in PXE patients is probably due to proximal obstructive lesions developing independently from cardiovascular risk factors.

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Section: Discussionsupporting

confidence: 89%

The Contribution of Arterial Calcification to Peripheral Arterial Disease in Pseudoxanthoma Elasticum

et al. 2014

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“…Donas et al performed balloon angioplasty for infrarenal aortic and iliac stenosis in one PXE patient, still patent at 12 months' of follow-up 3 . Siskos et al reported 6 months of patency after angioplasty with stenting at the iliac level in a 58-year-old patient 4 . Zimmo et al also reported patency after endovascular surgery in a PXE patient treated for a renal artery aneurysm 5 …”

Section: Discussionmentioning

confidence: 99%

Abnormally high failure rate for femoral angioplasty in patients with pseudoxanthoma elasticum

Ammi

Kranenburg

Omarjee

et al. 2015

Journal of Vascular Surgery Cases

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Pseudoxanthoma elasticum (PXE) is an inherited disease characterized by skin lesions, central blindness, and progressive peripheral occlusive disease. Severe claudication is a frequent symptom for which angioplasty represents a possible therapeutic avenue. We report the outcomes of four patients with PXE treated by angioplasty and stenting of the superficial femoral artery in two centers. These patients exhibited an abnormal failure rate for angioplasty and stenting of the superficial femoral artery, suggesting an as yet unknown susceptibility in such patients. In the absence of further evidence, we do not recommend arterial angioplasty with stenting as a primary surgical approach in PXE patients with femoral artery lesions.

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À la recherche d’un traitement idéal du lymphœdème. Compte-rendu de la 2e Conférence européenne de supermicrochirurgie (Barcelone – Mars 2012)

Rausky

Naeije

Binder

et al. 2012

Annales de Chirurgie Plastique Esthétique

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Case Report of a Patient With Iliac Occlusive Disease Due to Pseudoxantoma Elasticum and Review of the Bibliography

Cited by 7 publications

References 10 publications

The Contribution of Arterial Calcification to Peripheral Arterial Disease in Pseudoxanthoma Elasticum

The Contribution of Arterial Calcification to Peripheral Arterial Disease in Pseudoxanthoma Elasticum

Abnormally high failure rate for femoral angioplasty in patients with pseudoxanthoma elasticum

À la recherche d’un traitement idéal du lymphœdème. Compte-rendu de la 2e Conférence européenne de supermicrochirurgie (Barcelone – Mars 2012)

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