Case Report of Five Patients with Dyspepsia Improved after Korean Medicine Treatment, Including GeonChil Pharmacopuncture

Abstract

Obejective : Functional dyspepsia is a prevalent disease. It impedes subjective quality of life. The purpose of this research is to examine the equivalent effect of herb drug medicine treatment(H-D)and Over the Counter(OTC) for functional dyspepsia. Method :In this controlled study, we compared herb drug medicine(H-D) with Over the Counter(OTC) of functional dyspepsia. 30 volunteers who satisfied the requirements were enrolled in study. Severity of dyspepsia was measured by Nepean Dyspepsia Index(NDI-K) before and after treatments. Result :The results are summarized as follows.1. In Herb drug medicine and Over the Counter groups, total key symptoms score of after treatment were significantly decreased and improve rate of key symptoms was higher than before treatment, but there were no statistical significance between two groups.2. In Herb drug medicine and Over the Counter groups, each symptoms score of after treatment were significantly decreased and improve rate of key symptoms was higher than before treatment, but there were no statistical significance between two groups.3. In Herb drug medicine and Over the Counter groups, quality of life score of after treatment were significantly decreased and improve rate of key symptoms was higher than before treatment, but there were no statistical significance between two groups. Conclusion : Herb drug medicine treatment(H-D) is effective to improve the symptoms and quality of life in patients with functional dyspepsia.

Toxicity Assessment of a No-Pain Pharmacopuncture Extract Using a Standard Battery of In Vitro Chromosome Aberration Tests

“…In a safety study of NPP, no toxicity was detected in the single intramuscular administration toxicity test [12] and micronucleus test [13]. Furthermore, no special adverse reactions were indicated in a case report of plantar fasciitis [11]. Nevertheless, further research is needed to confirm the clinical safety of these ingredients.…”

“…No-pain (Mutong) pharmacopuncture (NPP) is a pharmawww.journal-jop.org copuncture solution that has been clinically used since 2022 to relieve musculoskeletal pain. To date, there have been few studies on NPP, including one case report [11] and two toxicity assessments [12,13]. The evaluation of genotoxicity is crucial in herbal medicines and traditional medicine practices as they have the potential to cause harmful mutations and damage genetic material, increasing the risk of diseases, such as malignant tumors [14].…”

In Vivo Genotoxicity Evaluation of a No-Pain Pharmacopuncture Extract Using the Micronucleus Test

“…The Jakyak-Gamcho decoction (PR and GR) is effective in relaxing gastrointestinal smooth and skeletal muscles and in relieving muscle spasms [17,18]. However, to the best of our knowledge, the efficacy or toxicity of NPP extract has not been previously evaluated, with the exception of one study that conducted a single-dose toxicity assessment [8], and a clinical report of efficacy in a case of plantar fasciitis [9]. Genotoxicity refers to the property of a substance to cause damage to cellular DNA or chromosomes [19].…”

“…It is made with qi formula (water type) to reduce pain during acupuncture and promote absorption [ 8 ]. However, while NPP continues to be used clinically, to the best of our knowledge, no studies have reported its efficacy and safety, other than a case report of one case of plantar fasciitis [ 9 ] and a single-dose muscle toxicity study [ 8 ].…”