Case report of mammary analog secretory carcinoma of the parotid gland

Ito, Shigemi; Ishida, Eiichi; Skálová, Alena; Matsuura, Kazuto; Kumamoto, Hiroyuki; Sato, Ikuro

doi:10.1111/j.1440-1827.2011.02759.x

Cited by 44 publications

(53 citation statements)

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“…[3][4][5][6][7] Immunohistochemistry studies may be useful in the differential diagnosis between mammary analog secretary carcinoma and its mimics. The former are reactive for S-100 protein and mammaglobin in the vast majority of cases, 1,[3][4][5][6]8 however, these two markers, S-100 in particular, are likewise found to be occasionally positive in other adenocarcinomas of salivary gland origin. Acinic cell carcinomas tend to be negative for mammaglobin, but can rarely demonstrate immunoreactivity for S-100.…”

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Searching for mammary analog secretory carcinoma of salivary gland among its mimics

et al. 2014

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Mammary analog secretory carcinoma of salivary gland is a recently described entity with unique morphologic, clinical, and genetic characteristics, including the characteristic t(12;15)(p13;q25) with ETV6-NTRK3 translocation found in secretory carcinomas of the breast. Before their initial description, these salivary gland tumors were generally diagnosed as acinic cell carcinoma or adenocarcinoma. For the purpose of this study, all cases of salivary gland acinic cell carcinoma, cribriform cystadenocarcinoma, and adenocarcinoma, not otherwise specified (NOS), diagnosed over a 10-year period were retrieved from our surgical pathology files. There were a total of 11 cases diagnosed as acinic cell carcinoma, 10 cases of adenocarcinoma, NOS, and 6 cases of cribriform cystadenocarcinoma. All slides were reviewed by two pathologists (AP, CGF) and tumors that show morphologic features of mammary analog secretory carcinoma according to the recent literature were selected. This process narrowed down the initial number to six cases originally diagnosed as acinic cell carcinoma, three cases originally diagnosed as adenocarcinoma, NOS, and one case originally diagnosed as cribriform cystadenocarcinoma. The 10 cases were subjected to immunohistochemistry for S-100, mammaglobin, and ANO1, as well as fluorescence in situ hybridization analysis for t(12;15)(p13;q25) with ETV6-NTRK3 fusion rearrangement. The ETV6-NTRK3 gene rearrangement was detected in three tumors. These three tumors, initially diagnosed as acinic cell carcinomas, stained positive for S-100 and mammaglobin, and negative for ANO1 by immunohistochemistry. Two of the three patients were male (2/3). In summary, mammary analog secretory carcinoma is a newly described diagnostic entity that should be in the differential diagnosis of salivary gland tumors that morphologically mimic other neoplasms, mainly acinic cell carcinomas. They differ from conventional acinic cell tumors immunohistochemically and molecularly. Positivity for mammaglobin and S-100, and negativity for ANO1 are useful screening tools before confirmatory molecular studies.

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Searching for mammary analog secretory carcinoma of salivary gland among its mimics

et al. 2014

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“…Moreover, 8 new cases of MASC have been documented as case reports within last two years [15][16][17][18][19][20].…”

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confidence: 99%

Mammary Analogue Secretory Carcinoma of Salivary Gland Origin: An Update and Expanded Morphologic and Immunohistochemical Spectrum of Recently Described Entity

Skálová

2013

Head and Neck Pathol

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135

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Mammary analogue secretory carcinoma of salivary gland origin (MASC) is a recently described tumor with ETV6 translocation. Akin to secretory breast cancer, MASC expresses S-100 protein, mammaglobin, vimentin, and harbors a t(12;15) (p13;q25) translocation which leads to ETV6-NTRK3 fusion product. Histologically, MASC displays a lobulated growth pattern and is often composed of microcystic, tubular, and solid structures with abundant eosinophilic homogeneous or bubbly secretions. Colloidlike secretory material stains positive for periodic acidSchiff (PAS) with and without diastase and for Alcian blue. The cells of MASC are devoid of PAS-positive secretory zymogen granules. These features help to exclude the most important differential diagnostic considerations, namely acinic cell carcinoma, low-grade cribriform cystadenocarcinoma, cystadenocarcinoma (not otherwise specified), and low-grade mucoepidermoid carcinoma. To date the presence of the ETV6-NTRK3 fusion gene has not been demonstrated in any other salivary gland tumor than MASC. It is likely that MASC is more common than currently recognized and with further studies, the clinical need for molecular studies of the ETV6-NTRK3 fusion may diminish. However, molecular testing is recommended at this time to arrive at the diagnosis of MASC.

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“…In addition, the authors found that these salivary gland tumors shared the immunophenotype and, remarkably, the characteristic ETV6-NTRK3 translocation of secretory breast carcinoma, and they accordingly designated them ''mammary analogue secretory carcinomas'' (MASCs). Since the initial description, MASC has been increasingly recognized, with 70 additional reported cases [2][3][4][5][6][7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Unmasking MASC: Bringing to Light the Unique Morphologic, Immunohistochemical and Genetic Features of the Newly Recognized Mammary Analogue Secretory Carcinoma of Salivary Glands

Bishop

2013

Head and Neck Pathol

120

142

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Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland neoplasm that is characterized by its striking morphologic and molecular similarities to secretory carcinoma of the breast. This review highlights the characteristic clinical, histologic, immunophenotypic, and molecular features of MASC, and draws attention to the differential diagnosis of this increasingly recognized tumor.

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Case report of mammary analog secretory carcinoma of the parotid gland

Cited by 44 publications

References 8 publications

Searching for mammary analog secretory carcinoma of salivary gland among its mimics

Searching for mammary analog secretory carcinoma of salivary gland among its mimics

Mammary Analogue Secretory Carcinoma of Salivary Gland Origin: An Update and Expanded Morphologic and Immunohistochemical Spectrum of Recently Described Entity

Unmasking MASC: Bringing to Light the Unique Morphologic, Immunohistochemical and Genetic Features of the Newly Recognized Mammary Analogue Secretory Carcinoma of Salivary Glands

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