Case report of meningoencephalitis during a concomitant mumps and parvovirus B19 infection

Yazawa, Shogo; Kawasaki, Shoichiro; Fujimoto, Chie; Ohi, Takekazu

doi:10.1016/s0303-8467(02)00030-6

Cited by 9 publications

(9 citation statements)

References 11 publications

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“…Lymphadenopathy (in most cases, cervical lymphadenopathy) was reported in 13 (16%) of 81 patients [6,14,17,21,27,29,36,39,43,47,54]. Nine (69%) of these patients were children.…”

Section: Epidemiologymentioning

confidence: 99%

“…Parotitis occurred in 2 patients [30,43]. Coinfection with Epstein-Barr or mumps virus was described in 2 patients with meningoencephalitis [20,21]. Encephalopathy, encephalitis, and meningoencephalitis.…”

Section: Epidemiologymentioning

confidence: 99%

“…The time to clinical improvement after IVIG administration varied, occurring as early as 2 days after administration in patients with encephalitis and several days after administration in patients with neuropathies [19,21,23]. Reversal of the abnormal magnetic resonance imaging findings within 8 days [19] and clinical improvement with simultaneous clearance of viremia after IVIG administration were also described [23,58].…”

Section: Epidemiologymentioning

confidence: 99%

“…Computed tomography of the brain had abnormal findings in some patients with CNS diseases, such as encephalitis, meningoencephalitis, or, in particular, stroke [17,23,51,55], whereas in others, findings were normal [14,18,21,51,52,54].…”

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confidence: 99%

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Neurologic Manifestations Associated with Parvovirus B19 Infection

2009

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Eighty-one cases of neurologic disease, including encephalitis, meningitis, stroke, and peripheral neuropathy, that were associated with parvovirus B19 infection were reviewed. Most patients were children, and two-thirds had central nervous system manifestations. One-third had altered immunity. Viral symptoms (odds ratio [OR], 5.7; P= .002), rash (OR, 11.5; P< .001), and peripheral nervous system involvement (OR, 12.1; P= .004) were more frequent in immunocompetent patients. Brain magnetic resonance imaging abnormalities were more frequent in patients with altered immunity (OR, 10; P= .04). In central nervous system disease, parvovirus B19 DNA was commonly detected in cerebrospinal fluid (81% of samples) and serum (85%), whereas specific antibodies were found in 33% of cerebrospinal fluid samples. Neurologic sequelae occurred in 22% of 77 patients with a known outcome, and some improvement occurred in 16%. No differences in the prevalence of sequealae were noted between immunocompetent patients (21% of whom experienced sequealae) and patients with altered immunity (25%) or between patients with central nervous system manifestations who received intravenous immunoglobulin with or without steroids and those patients with central nervous system manifestations who did not. Five patients died.

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“…Lymphadenopathy (in most cases, cervical lymphadenopathy) was reported in 13 (16%) of 81 patients [6,14,17,21,27,29,36,39,43,47,54]. Nine (69%) of these patients were children.…”

Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

mentioning

confidence: 99%

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Neurologic Manifestations Associated with Parvovirus B19 Infection

2009

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“…Guidi et al (4) reported the case of an ischemic stroke in a seven‐year‐old male after parvovirus B19 infection. Yazawa et al (5) and Akin et al (6) described the association of generalized convulsions during a concomitant mumps and parvovirus B19 infections. In their review, Wierenga et al (7) reported a total of 346 aplastic crises because of parvovirus B19 in patients with homozygous sickle cell disease, of which six patients presented with cerebrovascular complications and four patients with features of encephalitis.…”

Section: Discussionmentioning

confidence: 99%

Severe parvovirus B19 encephalitis after renal transplantation

Laurenz

Winkelmann

Roigas

et al. 2006

Pediatric Transplantation

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Human parvovirus B19 is a common cause of benign erythema infectiosum (fifth disease) in otherwise healthy children. Immunocompromized patients are at risk of developing chronic infections leading to chronic hyporegenerative anemia. We report the case of a nine-year-old boy who presented five days after renal transplantation with seizures and signs of encephalitis on MRI. The clinical course was characterized by anemia and seroconversion for parvovirus B19 accompanied by a high viral load (>10(9) copies per milliliter). A transfusion of red blood cells that the patient required after transplantation was found to be negative for parvovirus B19, leaving the donated organ as the most likely source of infection. Reduction of the immunosuppressive regimen led to complete recovery of the patient with a stable RBC count upon discharge. Parvovirus B19 infections should be considered in the differential diagnosis of seizures after solid organ transplantation.

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Neurological aspects of human parvovirus B19 infection: a systematic review

Barah

Whiteside

Batista

et al. 2014

Reviews in Medical Virology

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Parvovirus B19 has been linked with various clinical syndromes including neurological manifestations. However, its role in the latter remains not completely understood. Although the last 10 years witnessed a surge of case reports on B19-associated neurological aspects, the literature data remains scattered and heterogeneous, and epidemiological information on the incidence of B19-associated neurological aspects cannot be accurately extrapolated. The aim of this review is to identify the characteristics of cases of B19-associated neurological manifestations. A computerized systematic review of existing literature concerning cases of B19-related neurological aspects revealed 89 articles describing 129 patients; 79 (61.2%) were associated with CNS manifestations, 41 (31.8%) were associated with peripheral nervous system manifestations, and 9 (7.0%) were linked with myalgic encephalomyelitis. The majority of the cases (50/129) had encephalitis. Clinical characteristic features of these cases were analyzed, and possible pathological mechanisms were also described. In conclusion, B19 should be included in differential diagnosis of encephalitic syndromes of unknown etiology in all age groups. Diagnosis should rely on investigation of anti-B19 IgM antibodies and detection of B19 DNA in serum or CSF. Treatment of severe cases might benefit from a combined regime of intravenous immunoglobulins and steroids. To confirm these outcomes, goal-targeted studies are recommended to exactly identify epidemiological scenarios and explore potential pathogenic mechanisms of these complications. Performing retrospective and prospective and multicenter studies concerning B19 and neurological aspects in general, and B19 and encephalitic syndromes in particular, are required. © 2014 The Authors. Reviews in Medical Virology published by John Wiley & Sons, Ltd.

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Case report of meningoencephalitis during a concomitant mumps and parvovirus B19 infection

Cited by 9 publications

References 11 publications

Neurologic Manifestations Associated with Parvovirus B19 Infection

Neurologic Manifestations Associated with Parvovirus B19 Infection

Severe parvovirus B19 encephalitis after renal transplantation

Neurological aspects of human parvovirus B19 infection: a systematic review

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