Case Report of Periocular Merkel Cell Carcinoma Treated with Primary Concomitant Chemotherapy and Radiation, and Review of the Literature Regarding Its Use

Abstract

Introduction:

Periocular Cutaneous Malignancies: A Review of the Literature

“…166,172,182,185 MMS, frozen-section margin control, and 5-mm margins histologically confirmed to be tumor free have all been reported to be effective in sites that are not amenable to wide margins, such as the periocular region. 166,172,182,[185][186][187] One review found that most eyelid MCC are not treated with adjuvant radiation. 166,172,182,[185][186][187] One review found that most eyelid MCC are not treated with adjuvant radiation.…”

“…166 Exenteration is occasionally required. 182,187 Other Rare Periocular Malignancies 182,187 Other Rare Periocular Malignancies…”

“…126,172,185 The use of adjuvant radiation to the primary tumor site and positive nodal basins is controversial, with some studies demonstrating lower local and regional recurrence and others demonstrating no benefit with radiation. 166,172,182,[185][186][187] One review found that most eyelid MCC are not treated with adjuvant radiation. 166 Exenteration is occasionally required.…”

“…166,175 Adjuvant chemotherapy and combination treatments have been reported to be successful in limited cases; further investigation is needed for patients with node-positive and metastatic disease or those who are unable or unwilling to undergo surgery. 182,187 Other Rare Periocular Malignancies…”

Merkel cell carcinoma of skin-current controversies and recommendations

“…Controversies exist regarding the role of chemotherapy in terms of primary concomitant chemo-radiation, 36 and adjuvant chemotherapy after local treatment.…”