Case report of severe psychiatric sequelae in a 16-year-old female following resection of a purely dopamine-secreting ganglioneuroma

Chai, Louis F.; Ciullo, Sean; Prasad, Rajeev

doi:10.1016/j.ijscr.2019.07.028

Cited by 3 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The age range of our cases is 15 to 62 with a mean age of 35, which may be affected by the fact that there is no pediatric surgery department in PUMCH. So far, no other certain risk factors are found related to primary retroperitoneal GN except for possible familial predisposition (16).…”

Section: Discussionmentioning

confidence: 99%

Primary Retroperitoneal Ganglioneuroma: A Retrospective Cohort Study of 32 Patients

Xiao

Zhao

et al. 2021

Front. Surg.

View full text Add to dashboard Cite

Purpose: To investigate the clinical characteristics, diagnosis, differential diagnosis, therapy options, and outcomes of retroperitoneal ganglioneuroma.Methods: In this retrospective study, we collected and analyzed the clinical data of 32 patients diagnosed with retroperitoneal ganglioneuroma and admitted to Peking Union Medical College Hospital from October 2012 to August 2019.Results: Among our 32 cases with retroperitoneal ganglioneuroma, the male-to-female ratio was 1:3 and the mean age was 35. Only 25% of the cases presented with abdominal pain while more than 65% had no specific symptoms. The masses could be found through physical examination in only five patients. Most of the tumors are located near the renal area. They were usually single and displayed an embedded growth pattern with diameters <10 cm, clear borders, and soft texture. For radiological imaging, the majority of tumors demonstrated soft tissue density with mild-to-moderate enhancement on CT imaging and showed hypoecho with moderate blood flow signals in ultrasound. No significantly abnormal laboratory examinations were found in most patients. Of all the 32 patients, 2 chose surveillance after biopsy due to difficulties in operation, while others chose surgical resection. The mean follow-up time was 15.8 months among 26 patients. The tumor remained stable in the surveillance cases. Residual tumors were found in four cases receiving operations with no progress and discomfort. No recurrence was seen in all patients.Conclusions: The retroperitoneal ganglioneuroma is a benign tumor without specific clinical manifestations or significant laboratory findings. Typically, it is shown as low density with a clear border and an embedded growth pattern in radiological imaging. The overall prognosis is good. Surgery is an effective approach with possible severe complications. Incomplete resection or surveillance can be considered for some cases where complete resection is difficult to achieve.

show abstract

Section: Discussionmentioning

confidence: 99%

Primary Retroperitoneal Ganglioneuroma: A Retrospective Cohort Study of 32 Patients

Xiao

Zhao

et al. 2021

Front. Surg.

View full text Add to dashboard Cite

show abstract

“…Preoperative diagnostic imaging and functional tests are mandatory to evaluate, for example, tumor vessel invasion like in our case [1], spinal cord invasion [18][19][20][21]32], or potential hormoneproducing tumors especially in retroperitoneal/adrenal Exact max. size unknown, but < 10 cm according to the provided imaging cases [2,[13][14][15][16][17]. Approaches differ markedly depending on the center's expertise.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the required incision for the final in toto tumor removal from the abdominal cavity would render prior minimally invasive efforts futile. Preoperative diagnostic imaging and functional tests are mandatory to evaluate, for example, tumor vessel invasion like in our case [ 1 ], spinal cord invasion [ 18 – 21 , 32 ], or potential hormone-producing tumors especially in retroperitoneal/adrenal cases [ 2 , 13 – 17 ]. Approaches differ markedly depending on the center’s expertise.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, metanephrine detection in the plasma of patients is regarded as the gold standard for the detection of catecholamine-releasing tumors. These tumors are much more likely to cause symptoms such as hypertensive crisis, diarrhea, virilization due to hormonal imbalance, and depressive disorders [13][14][15][16][17]. Some studies indicate an association between a diagnosed ganglioneuroma and genetic diseases like multiple endocrine neoplasia type 2 or neurofibromatosis type 1 or 2 [3].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Total resection of a giant retroperitoneal and mediastinal ganglioneuroma—case report and systematic review of the literature

et al. 2020

View full text Add to dashboard Cite

Background Ganglioneuromas (GNs) are extremely rare, slowly growing, benign tumors that can arise from Schwann cells, ganglion cells, and neuronal or fibrous tissues. Due to their origin from the sympathetic neural crest, they show neuroendocrine potential; however, most are reported to be hormonally inactive. Nevertheless, complete surgical removal is recommended for symptom control or for the prevention of potential malignant degeneration. Case Report A 30-year-old female was referred to our oncologic center due to a giant retroperitoneal and mediastinal mass detected in computed tomography (CT) scans. The initial symptoms were transient nausea, diarrhea, and crampy abdominal pain. There was a positive family history including 5 first- and second-degree relatives. Presurgical biopsy revealed a benign ganglioneuroma. Total resection (TR) of a 35 × 25 × 25 cm, 2550-g tumor was obtained successfully via laparotomy combined with thoracotomy and partial incision of the diaphragm. Histopathological analysis confirmed the diagnosis. Surgically challenging aspects were the bilateral tumor invasion from the retroperitoneum into the mediastinum through the aortic hiatus with the need of a bilateral 2-cavity procedure, as well as the tumor-related displacement of the abdominal aorta, the mesenteric vessels, and the inferior vena cava. Due to their anatomic course through the tumor mass, the lumbar aortic vessels needed to be partially resected. Postoperative functioning was excellent without any sign of neurologic deficit. Conclusion Here, we present the largest case of a TR of a GN with retroperitoneal and mediastinal expansion. On review of the literature, this is the largest reported GN resected and was performed safely. Additionally, we present the first systematic literature review for large GN (> 10 cm) as well as for resected tumors growing from the abdominal cavity into the thoracic cavity.

show abstract

Endokrine Störungen

Kapfhammer¹

2022

Depression, Angst, Traumatischer Stress Und Internistische Erkrankungen

View full text Add to dashboard Cite

Case report of severe psychiatric sequelae in a 16-year-old female following resection of a purely dopamine-secreting ganglioneuroma

Cited by 3 publications

References 23 publications

Primary Retroperitoneal Ganglioneuroma: A Retrospective Cohort Study of 32 Patients

Primary Retroperitoneal Ganglioneuroma: A Retrospective Cohort Study of 32 Patients

Total resection of a giant retroperitoneal and mediastinal ganglioneuroma—case report and systematic review of the literature

Endokrine Störungen

Contact Info

Product

Resources

About