case report Oman Medical Journal [2017], Vol. 32, No. 5: 425-428 Human Parvovirus B19 in Children with Sickle Cell Disease; Poking the Spleen

Saad, Ashraf Abdullah; Beshlawi, Ismail; Al‐Rawas, Abdulhakim; Zachariah, Mathew; Nazir, Hanan; Wali, Yasser

doi:10.5001/omj.2017.79

Cited by 8 publications

(14 citation statements)

References 18 publications

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“…None demonstrated significant association of B19V IgG in with hemoglobin phenotypes, of which higher B19 IgG seroprevalence was revealed in Sickle Cell Anemic (SCA) patients than non-SCA controls. In consonance to our findings are the report of Saad et al (27) from a study of SCA patients screened for B19V infection. CONCLUSION Findings from this study revealed a high…”

Section: Conflict Of Interestsupporting

confidence: 93%

Association of Hemoglobin Electrophoretic Phenotype with Human Parvovirus B19 infection among Pregnant Women attending Abuja Tertiary Hospital, Nigeria

et al. 2020

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Section: Conflict Of Interestsupporting

confidence: 93%

Association of Hemoglobin Electrophoretic Phenotype with Human Parvovirus B19 infection among Pregnant Women attending Abuja Tertiary Hospital, Nigeria

et al. 2020

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“…In SCD patients, HPV B19 infection typically induces transient red cell aplasia (TRCA) through direct cellular toxicity to erythroid progenitors. Other complications such as acute glomerulonephritis, acute splenic sequestration and cerebrovascular events have also been described and are also the result of direct cellular toxicity or the consequence of severe anaemia in the context of TRCA [40][41][42][43][44]. Interestingly, immune mediated complications such as those observed in the general population have not been described in SCD [45,46].…”

Section: The Elusive Pathogenesismentioning

confidence: 99%

Fat Embolism Syndrome in Sickle Cell Disease

Tsitsikas

Vize

Abukar

2020

JCM

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Fat embolism syndrome is a devastating complication of sickle cell disease resulting from extensive bone marrow necrosis and associated with high mortality rates, while survivors often suffer severe neurological sequelae. Despite that, the syndrome remains under-recognised and under-diagnosed. Paradoxically, it affects exclusively patients with mild forms of sickle cell disease, predominantly HbSC and HbSβ+. A significant number of cases occur in the context of human parvovirus B19 infection. We provide here a brief summary of the existing literature and describe our experience treating 8 patients in our institution. One patient had HbSS, 6 HbSC and 1 HbSβ+. All patients developed type I respiratory failure and neurological involvement either at presentation or within the first 72 h. The most striking laboratory abnormality was a 100-fold increase of the serum ferritin from baseline. Seven patients received emergency red cell exchange and 1 simple transfusion. Two patients (25%) died, 2 patients (25%) suffered severe neurological impairment and 1 (12%) mild neurological impairment on discharge, while 3 (38%) patients made a complete recovery. With long-term follow-up, 1 patient with severe neurological impairment and one patient with mild neurological impairment made dramatic improvements, making the long-term complete recovery or near complete recovery rate 63%. Immediate red cell exchange transfusion can be lifesaving and should be instituted as soon as the syndrome is suspected. However, as the outcomes remain unsatisfactory despite the increasing use of red cell exchange, we suggest additional therapeutic measures such as therapeutic plasma exchange and pre-emptive transfusion for high risk patients.

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“…There is only a single autopsy demonstrating parvovirus inclusion bodies in the spleen at the time of aplastic crisis complicated by SSC, suggesting that a viral infection may be directly involved in the pathophysiology of splenic sequestration. 4 Simultaneous SSC, along with aplastic crisis, has been described in 5 children with SCD and parvovirus infection. 5 In a recent study, acute respiratory tract infections were identified as the most common etiology (55%) among 164 SSC episodes.…”

Section: Discussionmentioning

confidence: 99%

Documented Viral Illness at the Time of Splenic Sequestration Does Not Affect the Odds of Recurrence in Children With Sickle Cell Disease

Clement

Fishbein

Appiah‐Kubi

et al. 2022

Journal of Pediatric Hematology/Oncology

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This retrospective study investigates the relationship between the presence of a documented viral infection in children with sickle cell disease during their first splenic sequestration crisis and their odds of recurrence. Forty-eight children were admitted to our hospital between 2008 and 2018 with a splenic sequestration crisis. Thirty-six had respiratory viral panels done on admission, 13 of whom were positive. Two additional children were diagnosed with parvovirus B19 infection by serology. The recurrence rate was 52% (17/33) for those deemed negative for viral illness compared with 33% (5/15) among those with a positive documented viral illness, which was not statistically different (P=0.35). HbSC genotype decreased, and reticulocytosis increased the odds of recurrence. Further research is needed to substantiate these findings.

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case report Oman Medical Journal [2017], Vol. 32, No. 5: 425-428 Human Parvovirus B19 in Children with Sickle Cell Disease; Poking the Spleen

Cited by 8 publications

References 18 publications

Association of Hemoglobin Electrophoretic Phenotype with Human Parvovirus B19 infection among Pregnant Women attending Abuja Tertiary Hospital, Nigeria

Association of Hemoglobin Electrophoretic Phenotype with Human Parvovirus B19 infection among Pregnant Women attending Abuja Tertiary Hospital, Nigeria

Fat Embolism Syndrome in Sickle Cell Disease

Documented Viral Illness at the Time of Splenic Sequestration Does Not Affect the Odds of Recurrence in Children With Sickle Cell Disease

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