Case Report: Primary Ewing Sarcoma of the Penis

Das, Sudipta; Mishra, Satish; Rakshit, Kamalesh; Agarwal, Rahul

doi:10.1007/s13193-023-01793-x

Cited by 1 publication

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“…Although ES classically occurs in bone and soft tissues, its occurrence as a primary malignancy at extra-skeletal sites has been only infrequently reported in kidney, 16 lung, 5 esophagus, 10 ileum, 17 abdominal wall, 18 pelvis, 19 thyroid, 20 penis, 21 and female genital tract including ovary, 22 uterus 23 and cervix. 24 Fewer than 100 primary neuroectodermal tumors of the ovary have been reported in the literature, and bilateral primary ovarian ES is an even rarer occurrence, with only a handful of cases reported worldwide.…”

Section: Discussionmentioning

confidence: 99%

Bilateral primary ovarian Ewing sarcoma recurring as left submandibular lymphadenopathy diagnosed on cytology

Malik,

Madan,

Agrawal

et al. 2024

Autops Case Rep

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Ewing sarcoma (ES) is a highly malignant and aggressive small round-cell tumor originating from primitive neuroepithelium and mesenchymal stem cells. It is usually seen in children and adolescents with a male predilection and a preponderance to occur in long bones. Although skeletal/soft tissue ES is encountered in clinical practice, primary ES of the genital tract, particularly bilateral primary ovarian ES, is highly uncommon, with only a handful of cases reported worldwide. Ovarian ES is occasionally reported to involve para-aortic and pelvic lymph nodes in advanced stages. Still, cervical lymph node metastasis from ovarian ES is an infrequent clinical occurrence and, when present, indicates a worse prognosis. Here, we present an intriguing case of bilateral peripheral primary ovarian ES in an adult female, recurring as metastasis in the left submandibular lymph node. This case underlines the importance of keeping metastasis from ES as a possible differential while diagnosing metastatic small round cell tumors in peripheral lymph nodes. It also highlights the usefulness of a minimally invasive diagnostic modality of fine needle aspiration cytology and cell block preparation with applied ancillary techniques of immunohistochemistry and confirmatory molecular testing by fluorescence in-situ hybridization (FISH), for an accurate and quick diagnosis of such entities. The cytological diagnosis of our patient helped in the prompt and early initiation of chemotherapy without requiring any invasive procedure.

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