Case Report: Primary Leptomeningeal Medulloblastoma in a Child: Clinical Case Report and Literature Review

Abstract

Medulloblastoma is one of the most common pediatric central nervous system malignancies worldwide, and it is characterized by frequent leptomeningeal metastasizing. We report a rare case of primary leptomeningeal medulloblastoma of an 11-year-old Caucasian girl with a long-term disease history, non-specific clinical course, and challenges in the diagnosis verification. To date, 4 cases of pediatric primary leptomeningeal medulloblastoma are reported, and all of them are associated with unfavorable outcomes. The approaches of neuroimaging and diagnosis verification are analyzed in the article to provide opportunities for effective diagnosis of this disease in clinical practice. The reported clinical case of the primary leptomeningeal medulloblastoma is characterized by MR images with non-specific changes in the brain and spinal cord and by 18FDG-PET/CT images with diffuse heterogeneous hyperfixation of the radiopharmaceutical along the whole spinal cord. The immunohistochemistry and next-generation sequencing analyses of tumor samples were performed for comprehensive characterization of the reported clinical case.

Presentación leptomeníngea primaria de tumores con restricción en difusión. Presentación de dos casos

“…Según la literatura, se han descrito cinco casos de meduloblastomas con compromiso leptomeníngeo primario en pacientes pediátricos (7)(8)(9)(10)(11). Al revisar los trabajos previos a la clasificación de la OMS de 2016, se encuentra la descripción de 19 casos similares, pero con diagnóstico de tumor neuroectodérmico primitivo (PNET) (12).…”