CASE REPORT: Primary mesenteric root osteosarcoma in a dog

Abstract

A 10-year-old spayed female Boxer-mix was presented with a history of several weeks of soft stools, straining to defecate, inappetance, and lethargy and several days of hematochezia, melena, and dyschezia. Physical examination findings included mild tachycardia and tense cranial abdomen. CBC results indicated moderate mature neutrophilia. Ultrasonographic examination of the abdomen revealed a large mass with complex echogenicity in the cranial abdomen, likely associated with the intestines. Cytologic examination of a fine-needle aspirate revealed a population of round, stellate, and spindle-shaped cells arranged individually and in aggregates with occasional cells embedded in an eosinophilic extracellular matrix. The cytologic interpretation was malignant mesenchymal neoplasm with osteosarcoma being the primary differential. Surgical exploration of the abdomen revealed a 10-cm-diameter mass located at the intestinal mesenteric root. The mass occluded blood flow to portions of the gastrointestinal tract. The dog was euthanized due to the nonresectable nature of the tumor. Histopathologic examination revealed an expansile poorly demarcated mesenchymal neoplasm composed predominantly of spindloid and pyriform cells, occasionally embedded in a matrix compatible with osteoid. The diagnosis was extraskeletal osteosarcoma of the intestinal mesenteric root, only rarely reported in dogs.

SEGMENTO CAUDAL DA ARTÉRIA AORTA ABDOMINAL E SUAS RAMIFICAÇÕES EM QUATI (Nasua nasua) Linnaeus, 1766

“…Em jaguatirica, segundo Pinheiro et al (2014), ocorre o mesmo padrão de origem e distribuição observado em quati. Várias patologias podem afetar o intestino, como torções, intuscepção, tumores e isquemia, daí a importância de se conhecer o padrão de vascularização intestinal, visando um atendimento clínico de qualidade (RAHAL et al, 2000;ZERBIB et al, 2008;URBIZTONDO et al, 2010).…”

The importance of clinical, histopathological and immunohistochemical marking for differential diagnosis of non-hematopoietic gastrointestinal mesenchymal neoplasms in dogs: literature review

“…Osteoblastic osteosarcoma is the most common histological type, being reported in 63.6% of cases of extrahepatic canine osteosarcoma, mainly affecting the mammary gland, spleen, testicles, eyes, vagina, kidneys, and liver (LANGENBACK et al, 1998;URBIZTONDO et al, 2010;DUFFY et al, 2017).…”

“…Macroscopically, these neoplasms are large tumors, whose measurements vary from 2.5 to 30 cm in diameter with a mean of 12.7 cm, which present irregular surfaces that extend from the intestinal muscle layers to the mucosa (LANGENBACK et al, 1998;URBIZTONDO et al, 2010;DUFFY et al, 2017). These tumors are characterized by polygonal mesenchymal cells with pleomorphic fusiform, with large vesicular nucleus and eosinophilic cytoplasm.…”

“…Intra-abdominal osteosarcomas present an aggressive behavior and worse prognosis associated with a high mortality rate when located in the gastrointestinal tract and liver (LANGENBACK et al, 1998;URBIZTONDO et al, 2010;MACKENZIE, et al, 2012;DUFFY et al, 2017). Table 3 summarizes the main references that address the anatomopathological characteristics of gastrointestinal neoplasias affecting dogs according to segment of the gastrointestinal tract, intestinal wall location, immunomarkers and survival after diagnosis.…”

Osteosarcoma extraesquelético retroperitoneal en un perro: reporte de un caso

“…Se caracteriza por la formación de tejido osteoide en órganos viscerales y tejidos blandos, sin que exista relación con tejido óseo o periostial (Patnaik 1990;Langenbach et al 1998;Spugnini et al 2001;van de Sant et al 2004;Urbiztondo et al 2010;Mackenzie et al 2012;Marcus et al 2012;Timian et al 2012). Representan cerca del 1% de los osteosarcomas (Woldemeskel & Grice 2011;Timian et al 2012).…”