Case Report: Primary Squamous Cell Carcinoma of a Tarsal Bone

Abstract

We describe a rare case of primary squamous cell carcinoma of the cuneiform bone of the foot in a 57-year-old man. In the appendicular skeleton, epithelial carcinomas of bone are usually metastatic deposits, primary squamous cell carcinomas of bone being found more frequently in the skull. A review of the English literature revealed only two other reported cases of primary squamous cell carcinoma outside the skull--one in the ilium and one in the tibia. In our patient, extensive metastatic workup and monitoring during more than 2 years showed no primary focus, supporting the rare presentation of a primary squamous cell carcinoma of bone in the appendicular skeleton.

Primary nonkeratinizing squamous cell carcinoma of the scapular bone: A case report

“…This is because our patient had a poorly differentiated SCC, while the previous three patients had well-differentiated SCCs with keratin pearl formation. The immunohistochemical features of the previous three cases were also similar to those of our case[ 5 - 7 ], in that the tumor cells were reactive to cytokeratin 5/6, p63, and p40[ 20 - 22 ]. However, in our case, the tumor cells were also reactive to vimentin, which may be related to the metastasis capability and invasiveness of the primary SCC[ 23 ].…”

“…Squamous cell carcinoma (SCC) is the second most common non-melanoma skin cancer. Although SCC can metastasize to other organs such as the bones[ 1 - 4 ], primary SCC of the bone is rare due to the absence of native squamous epithelium in osseous tissue[ 5 ]. When primary SCC does affect the bones, the most common site of involvement is the skull.…”

“…When primary SCC does affect the bones, the most common site of involvement is the skull. Indeed, only three cases of primary SCC at other sites in the skeletal system, namely, the iliac bone, distal tibia, and tarsal bone, have been reported in the English literature[ 5 - 7 ]. Herein, we report the fourth case of primary SCC of a non-skull bone, which is also the first case of primary nonkeratinizing SCC of the scapula.…”

Multiple Primary Malignant Neoplasms: An Unusual Case of Metachronous Breast Ductal and Squamous Cell Carcinomas

“…Bone metastasis of squamous cell carcinoma is seen in 30-40% of those with advanced lung cancer and only seen in 10% of all head and neck squamous cell carcinoma [10,11]. Primary squamous cell carcinoma of bone is rare in the skeletal system other than in the skull, with only three such cases reported in the English literature [12][13][14].…”