Case Report: Prolonged CSF PCR Positivity in a Neonate With GBS Meningitis

Alruqaie, Nourah; Falatah, Yara; Alzahrani, Fawaz; Alharbi, Musaed

doi:10.3389/fped.2021.752235

Cited by 3 publications

(4 citation statements)

References 36 publications

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“…Adults previously treated with antibiotics as short as one day duration may have negative GBS culture from CSF [21] . Prolonged GBS CSF PCR positivity has been demonstrated to be related to persistent infection in a neonate with ventriculitis and residual brain abscess [22] suggesting that test positivity can be associated with residual infection. An Irish multicenter diagnostic accuracy study comparing CSF PCR with culture in infants with late-onset GBS meningitis found the test to be 100% sensitive with a specificity of 97% [23] .…”

Section: Discussionmentioning

confidence: 99%

Mania: An atypical presentation of probable Streptococcus agalactiae meningoencephalitis

Hudson

Bobo

Prada

et al. 2023

IDCases

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Section: Discussionmentioning

confidence: 99%

Mania: An atypical presentation of probable Streptococcus agalactiae meningoencephalitis

Hudson

Bobo

Prada

et al. 2023

IDCases

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“… 4 Gram-negative bacteria such as Klebsiella and E. coli have been reported as highly prevalent in Saudi Arabia. 5 While Haemophilus influenzae type b (Hib) (57%), Streptococcus pneumoniae (31%), and group B streptococcus (7.5%) have been identified as significant contributors to NM in Saudi Arabia. 6 A sporadic case of Elizabethkingia meningoseptica meningitis in an extremely premature infant with low birth weight was reported in Saudi Arabia.…”

Section: Introductionmentioning

confidence: 99%

Late-Onset Meningitis in a Preterm Infant Caused by Streptococcus gallolyticus Subsp. Pasteurianus in Saudi Arabia: A Case Report and Literature Review

Al-shehri

2023

IMCRJ

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This report describes the progression of meningitis in a 24-day-old preterm male infant infected with Streptococcus gallolyticus subsp. pasteurianus (SGSP) and its medical care, pathogen detection, antibiotic treatment, and monitoring, ultimately leading to a positive outcome of successful recovery. Neonatal meningitis (NM) is a serious and potentially life-threatening condition, particularly in immunocompromised preterm infants. This report from Saudi Arabia presents a rare case of late-onset neonatal meningitis caused by SGSP in a preterm male infant. The 24-day-old preterm neonate presented with fever, lethargy, poor feeding, and respiratory distress. SGSP was confirmed by cerebral spinal fluid analysis showing the presence of pleocytosis and a low glucose ratio. Prompt antibiotic therapy with intravenous Ampicillin and Cefotaxime led to decreased pleocytosis, and the infant was discharged after 21 days. This report highlights the importance of vigilance, diagnosis, and management of neonatal infections caused by uncommon pathogens such as SGSP. The rarity of SGSP-caused meningitis emphasizes the need to monitor pregnant women for potential transmission and to implement early diagnostic and management strategies. This case report also encompasses a review of recent globally reported cases of neonatal S. gallolyticus infection, highlighting the distinctiveness of this report as the first of its type in Saudi Arabia.

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“…Clinicians must be able to detect the clinical manifestations of meningitis, as well as comprehend its therapy and prevention. The elimination of the invading organism from fluid surrounding the brain and spinal cord is fully reliant on antimicrobial treatment that must be started as momentarily as conceivable following the diagnosis of bacterial meningitis [4][5][6][7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

“…Antimicrobials are critical in lowering the mortality rate of infectious illnesses. Despite improvements in the healthcare system and medicines, the growing death rate is concerning 6 .…”

Section: Introductionmentioning

confidence: 99%

Traditional and molecular methods for diagnosing bacterial meningitis in Erbil city, Iraq

Hamaameen,

Khider

2023

Baghdad Sci.J

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Bacterial meningitis is a leading cause of illness and death worldwide. It is crucial for clinical and public health care, as well as disease control, to identify the meningitis-causing agent promptly. Between June 2021-February 2022, a total of 100 cerebrospinal fluid (CSF) and blood samples were collected from suspected cases of meningitis admitted to Raparin Paediatric Teaching Hospital, Erbil city-Iraq. Cytochemical, cultural, and biochemical tests were conducted, and confirmed by molecular techniques. Bacterial culture findings were positive in 7% of CSF samples and just one positive among blood samples. The most common pathogens found by cultural characteristics and VITEK 2 Compact System were Staphylococcus sciuri in two cases 2%, Staphylococcus xylosus in one case 1%, Escherichia coli in two instances 2%, Enterococcus casseliflavus and Micrococcus luteus each in one case 1%. Staphylococcus sciuri, Staphylococcus xylosus, Enterococcus casseliflavus and Micrococcus luteus were first recorded as bacterial meningitis in Erbil/Iraq. All isolates were confirmed by PCR assay. All clinical isolates were screened for some antimicrobial sensitivity, meropenem and tobramycin have been shown to be totally resistant 100% to all isolated bacteria, furthermore, isolated E coli showed highly resistant 100 to cefotaxime, gentamycin, pencillin, ceftriaxone, rifampin, amoxicillin/clavulanic acid, ceftazidime, erythromycin, ampicillin, and clindamycin, while they were sensitive (100%) to amikacin and imipenem as well as all the gram positive bacteria were resistant 100% to optochin and sensitive (100%) to gentamycin, and trimethoprim. In bacterial meningitis patients, high C-reactive protein (CRP) >6 mg/dl, high CSF protein >50 mg/dl, low CSF glucose level <40 mg/dl and high leukocyte count >100 cells/mm3 were all substantially diagnostic.

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Case Report: Prolonged CSF PCR Positivity in a Neonate With GBS Meningitis

Cited by 3 publications

References 36 publications

Mania: An atypical presentation of probable Streptococcus agalactiae meningoencephalitis

Mania: An atypical presentation of probable Streptococcus agalactiae meningoencephalitis

Late-Onset Meningitis in a Preterm Infant Caused by Streptococcus gallolyticus Subsp. Pasteurianus in Saudi Arabia: A Case Report and Literature Review

Traditional and molecular methods for diagnosing bacterial meningitis in Erbil city, Iraq

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