Case Report: Pulmonary Papillomatosis in a Patient Presenting with Cough and Hemoptysis

Zhang, Zhou; Chang, Melisa; Moreta-Sainz, Luis

doi:10.7812/tpp/14-192

Cited by 7 publications

(7 citation statements)

References 12 publications

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“…In studies carried out between 1950 and 1980 comprising 532 cases, the order of frequency of the disease’s propagation was in the true vocal cords, the oral cavity, the trachea, the bronchi, and the esophagus. In 2%–17% of RRP cases, the propagation occurred through to the distal trachea and bronchi, and less than 1% to the pulmonary parenchima, 6 , 15 - 17 as observed in our case. However, Gélinas et al 10 brought together cohort studies on RRP, and of the 1666 patients with the disease 55 (3.3%) had pulmonary involvement.…”

Section: Discussionsupporting

confidence: 52%

“…RRP is clinically divided according to the age of onset: JORRP is used to describe the disease when it primarily manifests in children around the age of 2 to 4 years, and adult-onset recurrent respiratory papillomatosis (AORRP) when it manifests mainly between the ages of 20 and 40 years. 6 Although the lesion is benign in nature, RRP may present an aggressive clinical course among children and can be fatal because of its repeated recurrence and spread throughout the respiratory tract. 7 …”

Section: Discussionmentioning

confidence: 99%

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Juvenile-onset recurrent respiratory papillomatosis with pulmonary involvement and carcinomatous transformation

et al. 2018

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Papilloma associated with recurrent respiratory papillomatosis (RRP), caused by human papilloma virus (HPV) infection types 6 and 11, is the most common benign neoplasm of the larynx. The clinical features of RRP vary widely from mild to aggressive forms. RRP in children is known as juvenile-onset recurrent respiratory papillomatosis (JORRP). Its outcome may be poor or even fatal due to the high rate of recurrence and eventual spread to the entire respiratory tract. Pulmonary invasion is reported to occur in 3.3% of patients with RRP, and malignant transformation in 0.5% of patients. We report the case of a 39-year-old female patient with a diagnosis of JORRP from the age of 3 years, with extensive bilateral pulmonary involvement and malignant transformation. Analysis of the papilloma and carcinomatous tissues revealed the presence of HPV type 11, which is associated with rapid and aggressive progression. We discussed the case on the basis of a literature review on pulmonary invasion, malignant transformation, and HPV 11 aggressiveness.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Juvenile-onset recurrent respiratory papillomatosis with pulmonary involvement and carcinomatous transformation

et al. 2018

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“…LP has bimodal incidence -the juvenile-onset RRP (JORRP) typically occurring in children aged 2-4 years and adult-onset RRP typically occurring in the third and fourth decades of life. Boys and girls appear to be nearly equally affected in JORRP, whereas adult-onset papillomas are more common in males (2:1) [1]. Our patient presented for the 1 st time in the eight decade of life.…”

Section: Discussionmentioning

confidence: 69%

“…The condition is caused by human papillomavirus (HPV) serotypes 6, 11, 16, and 18. HPV infects the mucosal basal layer and induces cellular proliferations by activating host replication genes through epidermal growth factor receptor pathway, resulting in thickening of the basal layer and development of a papilloma which appears grossly as velvety or exophytic "cauliflower" [1,2].…”

mentioning

confidence: 99%

Decoding atypical laryngeal growths – A case report

DUTTA¹,

Ghosh²,

CHATTERJEE³

et al. 2024

Eastern J Med Sci

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Respiratory papillomatosis is a relatively rare disease with a potential for devastating consequences. The viral etiology of this condition has been well established. Most often, the wart is successfully managed surgically. Post surgical removal, there exists a high chance of recurrence of the papilloma. It has been documented that surgical removal followed by an adjuvant therapy helps to delay the recurrence. Also, the use of quadrivalent human papillomavirus vaccine is expected to decrease the incidence of respiratory papillomatosis or help with treatment of the disease in the years to come. Here we discuss an unusually late presentation of adult-onset laryngeal papilloma that was managed with some deviation from the routine.

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“…Our report highlights the rapid progression to SCC; the patient presented symptoms for only 4 months and the malignant lesion was diagnosed together with papillomatosis; it being able to attribute this to an aggressive progression of high-risk HPV 16. The rarity of cases in which the malignant transformation has a rapid course was observed; in 3 reported cases, the patients did not have recurrent disease, and in 1 case, the carcinoma was detected only 6 months after the diagnosis of LP [20]. Other factors associated with more aggressive LP are the higher number of recurrences and evolution time greater than 10 years [5].…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature

El‐Achkar

Duarte

Saggioro

et al. 2018

Case Reports in Otolaryngology

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Background The malignant transformation of laryngeal papillomatosis (LP) into squamous cell carcinoma (SCC) can occur in up to 4% of LP cases. The low-risk HPV types 6 and 11 are those that are most commonly related to LP; however, high-risk HPV types may be present. The present study reviews the literature on cases of malignant transformation of LP in adults and reports a clinical case. Case Report A 47-year-old male patient exhibiting hoarseness for 4 months presented an exophytic lesion in the right palatine tonsil and a digitiform-like lesion in the right vocal fold. The biopsy revealed a well-differentiated SCC in the vocal cord, which showed a transition zone with a squamous papillomatous lesion. By using the chromogenic in situ hybridization (CISH) test, both lesions showed a positive result for high-risk HPV types 16 and 18 and negative for low-risk HPV types 6 and 11. The final diagnosis was SCC arising from LP. The patient underwent surgical treatment. After 36 months of follow-up, no signs of recurrence were observed. Results The literature review revealed 25 cases of malignant transformation into SCC of LP with adult onset. Of these, only 9 cases were assessed by CISH and/or PCR for HPV identification, of which 7 were positive. The current study focuses on the eighth case, suggesting the involvement of the high-risk HPV types in its pathogenesis. Conclusions LP is considered a benign lesion with the potential for malignant transformation, which reinforces the need for its early diagnosis and the constant monitoring of patients with LP.

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Case Report: Pulmonary Papillomatosis in a Patient Presenting with Cough and Hemoptysis

Cited by 7 publications

References 12 publications

Juvenile-onset recurrent respiratory papillomatosis with pulmonary involvement and carcinomatous transformation

Juvenile-onset recurrent respiratory papillomatosis with pulmonary involvement and carcinomatous transformation

Decoding atypical laryngeal growths – A case report

Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature

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