Case Report: Retransplantation Due to Hepatocellular Carcinoma After Direct Antiviral Agents in Cirrhotic Patients

Abstract

Introduction. Direct antiviral agents had opened new opportunities of treatment for chronic hepatitis C (HCV) in patients with cirrhosis. However, patients with decompensated liver cirrhosis need special attention and individual approach before antiviral therapy prescription.The aim of the study — to demonstrate a clinical case probability of developing liver cirrhosis complications aſter effective antiviral therapy.Materials and methods. Analysis of medical records of 52 уears old male with HCV-associated liver cirrhosis who was treated with direct antiviral agents with achieving of sustained virologic response (SVR). During follow up hepatocellular carcinoma (HCC) was detected. Patient underwent a liver transplantation complicated by primary non function liver graſt in the early postoperative period. Liver retransplantation with necessity of extracorporeal treatment methods and complex immunosuppressive therapy.Discussion. Antiviral treatment of patients with decompensated liver cirrhosis does not always improve prognosis and sustained SVR does not exclude risk of HCC appearance.Conclusion. Treated patients should be included in monitoring and HCC surveillance program.