Case Report: Squamous Cell Carcinoma Referred for Mohs Surgery Found to be Cutaneous Leishmaniasis

Prieto, Manuel; Uribe-Restrepo, Andrés Felipe; Arcos, D.; Vargas, Diana

doi:10.4269/ajtmh.18-0243

Cited by 8 publications

(10 citation statements)

References 23 publications

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“…In fact, histopathologic evaluation in chronic lesions might be confusing due to the presence of pseudoepitheliomatous hyperplasia as a response to chronic irritation of epithelium which can mimic SCC 8 . However, it is worthy to note that actual SCC can also develop over chronic CL lesions as happened to our first case and after multiple tissue samples with only pseudoepitheliomatous hyperplasia, SCC was noted in the last one.…”

Section: Discussionmentioning

confidence: 71%

Two cases of neglected leishmaniasis with marked facial disfigurement: A diagnostic conundrum

Aryanian,

Balighi,

Mohaghegh

et al. 2023

Clinical Case Reports

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Key Clinical MessageThere is a need to pay more attention to cutaneous leishmaniasis in endemic regions which may mimic other dermatoses and treatment should be initiated with a strong clinical suspicion even without any histopathologic or PCR confirmation to avoid disfigurement or development of secondary malignancy.AbstractLeishmaniasis is a vector‐borne disease with a variety of Clinical manifestations. Cutaneous leishmaniasis (CL) is the most common form of disease and can mimic other dermatoses. We describe two unusual cases of chronic leishmaniasis that remained undiagnosed for many years and led to superimposition of squamous cell carcinoma (SCC) on lesions of one patient. These reports showed that the leishmaniasis should be borne in mind by clinicians when encountering any infiltrated lesion in patients from endemic regions and treatment should be initiated with a strong clinical suspicion even without any histopathologic or PCR confirmation to avoid disfigurement or development of secondary malignancy.

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Section: Discussionmentioning

confidence: 71%

Two cases of neglected leishmaniasis with marked facial disfigurement: A diagnostic conundrum

Aryanian,

Balighi,

Mohaghegh

et al. 2023

Clinical Case Reports

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“…In a case study a patient with chronic lesion on the face was directed to histopathological examination after pre-diagnosis of squamous cell carcinoma, and eventually diagnosed with Leishmaniasis . The patient got recovered after treated with miltefosine ( 24 ). In our study, positive three patients who applied to plastic surgery with plaques, nodule, mass of lesion type were found leishmaniasis with kDNA-PCR.…”

Section: Discussionmentioning

confidence: 99%

The Investigation of the Association of Cutaneous Leishmaniasis in Biopsy Specimens of the Patients with Granulomatous Disease and Skin Cancer Using the Molecular Method

Çulha

Doğramacı

Hakverdı

et al. 2020

IJPA

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Background: Clinically, cutaneous leishmaniasis (CL) can be confused with granulomatous diseases and skin cancers, and it may lead to erroneous diagnosis and treatment. Diagnosis based and histopathology can have some difficulties due to low number of parasites, especially in chronic CL cases. We aimed to emphasize the necessity of considering CL in the differential diagnosis for cases of granulomatous diseases and basal cell carcinoma, particularly in areas where CL is endemic. Methods: One hundred and seven paraffin-embedded tissue biopsy specimens were selected from the archive, as of 2002, of Pathology Department, School of Medicine, University of Hatay Mustafa Kemal in Hatay, Turkey. After DNA isolation, performed with the samples were used for PCR analysis with specific 13A, 13B primers targeting kinetoplastid DNA (kDNA) found in all Leishmania species. Another PCR was performed with LITSR and L5.8S primers targeting ITS-1 internal-transcribed-spacer-1 (ITS-1) region to subtype positive samples. Then these samples were further analyzed for subtyping with PCR-RFLP using HaeIII enzyme (BsuRI). Results: Ten out of 107 tissue specimens were positive via kDNA-PCR. Lupus vulgaris, sarcoidosis, skin lymphoma and Leishmania cutis appeared in 9 out of 10 positive specimens. One of the cases presented with a mass on the cheek and was pre-diagnosed with hemangioma, but leishmaniasis did not appear. All of 10 specimens were diagnosed as granulomatous dermatitis. Two out of 10 samples, found positive with kDNA-PCR, were analyzed with ITS-1-PCR and identified as L. infantum/donovani after RFLP. Conclusion: Molecular methods should be utilized in the differential diagnosis of CL to eliminate false diagnoses of granulomatous diseases and skin cancers.

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“…Leishmaniasis lesions can be confused, in many cases, with neoplastic changes in the skin, being reported diagnoses of carcinoma discarded by histopathological studies that confirm the absence of neoplastic lesion [19], [20]. Currently, it has become the second mosquito-borne parasite disease with the highest incidence in Panama, after Malaria [17].…”

Section: B Leishmaniasismentioning

confidence: 99%

Vector Borne Diseases Related with Companion Animals in Panama: A Review

Chacón¹

2023

EJVETMED

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Zoonoses are, in a broad sense, diseases transmitted to humans through direct or indirect contact with animals (vertebrates or invertebrates), their environment or by-products. There are different concepts, definitions and classifications of zoonoses according to different criteria. There are different concepts, definitions, and classifications of zoonoses following several criteria. Vectors are transmission vehicles that carry etiological agents between different animal species, including man, or between the environment and these species. The Republic of Panama is an interoceanic isthmus that meets all the basic conditions for the development of vector-borne diseases. This review provides a chronological analysis of the vectorial zoonoses related to companion animals or those that have a close relationship with humans. The history of studies on Trypanosomiasis, Leishmaniasis, Babesiosis, Hepatozoonosis, Rickettsiosis, Ehrlichiosis, Anaplasmosis, Bartonellosis, Borreliosis, Equine Encephalitis, Dirofilariasis and Dipylidiasis in Panama shows that environmental, socioeconomic, cultural, evolutive, investigative and educational factors have a direct influence on the success or failure in the control and prevention of these vectorial zoonoses. For this reason, major efforts are needed in relation to research and work that provide real data to support control programs for these diseases.

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Case Report: Squamous Cell Carcinoma Referred for Mohs Surgery Found to be Cutaneous Leishmaniasis

Cited by 8 publications

References 23 publications

Two cases of neglected leishmaniasis with marked facial disfigurement: A diagnostic conundrum

Two cases of neglected leishmaniasis with marked facial disfigurement: A diagnostic conundrum

The Investigation of the Association of Cutaneous Leishmaniasis in Biopsy Specimens of the Patients with Granulomatous Disease and Skin Cancer Using the Molecular Method

Vector Borne Diseases Related with Companion Animals in Panama: A Review

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