Case report—Subcorneal pustular dermatosis—A great mimicker of generalized pustular psoriasis

Affandi, Azura Mohd; Baharom, Zuliatul F

doi:10.1111/exd.14800

Cited by 4 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, it was noted that IL36RN alterations may not serve as a reliable distinguishing factor, as they have been identified in cases of AGEP . It was also agreed that hypopyon pustules, characterized by clear fluid in the upper half and purulent yellow fluid in the lower half, support the diagnosis of SPD, a rare, benign, relapsing pustular dermatosis without systemic symptoms . While there was unanimous agreement (100%) that a biopsy should be performed to rule out differential diagnoses of GPP, there was no consensus (32%) on the use of direct immunofluorescence to identify or rule out pemphigus.…”

Section: Discussionmentioning

confidence: 99%

International Consensus Definition and Diagnostic Criteria for Generalized Pustular Psoriasis From the International Psoriasis Council

Choon,

van de Kerkhof,

Gudjonsson

et al. 2024

JAMA Dermatol

View full text Add to dashboard Cite

ImportanceGeneralized pustular psoriasis (GPP) lacks internationally accepted definitions and diagnostic criteria, impeding timely diagnosis and treatment and hindering cross-regional clinical and epidemiological study comparisons.ObjectiveTo develop an international consensus definition and diagnostic criteria for GPP using the modified Delphi method.Evidence ReviewThe rarity of GPP presents a challenge in acquiring comprehensive published clinical data necessary for developing standardized definition and criteria. Instead of relying on a literature search, 43 statements that comprehensively addressed the fundamental aspects of the definitions and diagnostic criteria for GPP were formulated based on expert reviews of 64 challenging GPP cases. These statements were presented to a panel of 33 global GPP experts for voting, discussion, and refinements in 2 virtual consensus meetings. Consensus during voting was defined as at least 80% agreement; the definition and diagnostic criteria were accepted by all panelists after voting and in-depth discussion.FindingsIn the first and second modified Delphi round, 30 (91%) and 25 (76%) experts participated. In the initial Delphi round, consensus was achieved for 53% of the statements, leading to the approval of 23 statements that were utilized to develop the proposed definitions and diagnostic criteria for GPP. During the second Delphi round, the final definition established was, “Generalized Pustular Psoriasis is a systemic inflammatory disease characterized by cutaneous erythema and macroscopically visible sterile pustules.” It can occur with or without systemic symptoms, other psoriasis types, and laboratory abnormalities. GPP may manifest as an acute form with widespread pustules or a subacute variant with an annular phenotype. The identified essential criterion was, “Macroscopically visible sterile pustules on erythematous base and not restricted to the acral region or within psoriatic plaques.”Conclusions and RelevanceThe achievement of international consensus on the definition and diagnostic criteria for GPP underscores the importance of collaboration, innovative methodology, and expert engagement to address rare diseases. Although further validation is needed, these criteria can serve as a reference point for clinicians, researchers, and patients, which may contribute to more accurate diagnosis and improved management of GPP.

show abstract

Section: Discussionmentioning

confidence: 99%

International Consensus Definition and Diagnostic Criteria for Generalized Pustular Psoriasis From the International Psoriasis Council

Choon,

van de Kerkhof,

Gudjonsson

et al. 2024

JAMA Dermatol

View full text Add to dashboard Cite

show abstract

“…Case series and reports included in this special issue highlight the diverse clinical phenotypes of GPP and underscore the importance of individualized care. They address challenges in accurate diagnosis, explore potential treatments and emphasize the need for medication review to identify potentially triggering agents 7–11 …”

mentioning

confidence: 99%