Case Report: Successful Epiradicular Peripheral Nerve Stimulation of the C2 Dorsal Root Ganglion for Postherpetic Neuralgia

Lynch, Paul; McJunkin, Tory; Eross, Eric J.; Gooch, Stacie; Maloney, Jillian

doi:10.1111/j.1525-1403.2010.00307.x

Cited by 45 publications

(36 citation statements)

References 26 publications

(31 reference statements)

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“…Treating PHN is a major problem, it has challenged pain physicians and neurosurgeons for decades. The results we are observing with DRG stimulation so far are somewhat mixed . No comprehensive overview has been published so far and no common sense inside the neuromodulation society exists regarding recommendation for DRG stimulation in PHN.…”

Section: Discussionmentioning

confidence: 99%

Cervical and High-Thoracic Dorsal Root Ganglion Stimulation in Chronic Neuropathic Pain

Piedade

Vesper

Chatzikalfas

et al. 2019

Neuromodulation: Technology at the Neural Interface

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Section: Discussionmentioning

confidence: 99%

Cervical and High-Thoracic Dorsal Root Ganglion Stimulation in Chronic Neuropathic Pain

Piedade

Vesper

Chatzikalfas

et al. 2019

Neuromodulation: Technology at the Neural Interface

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“…Electrical stimulation of the DRG can reduce neuronal excitability and the idea that dorsal root ganglion stimulation (DRGS) may be directly treating pathological neurons makes it an alluring target. To date DRGS has been used to treat postherpetic neuralgia , phantom limb pain (PLP) , failed back surgery syndrome (FBSS) post herniorrhaphy groin pain , radicular pain , complex regional pain syndrome (CRPS) of the foot , knee and distal upper limb , postsurgical perineal pain , pelvic girdle pain , peripheral nerve injury following kidney surgery , pain following femoral vascular access , and pain following deep vein thrombosis (DVT) amongst other unpublished indications.…”

Section: Introductionmentioning

confidence: 99%

The Efficacy and Safety of Dorsal Root Ganglion Stimulation as a Treatment for Neuropathic Pain: A Literature Review

Harrison

Epton

Bojanić

et al. 2018

Neuromodulation: Technology at the Neural Interface

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There is now Class A RCT evidence that DRGS provides superior pain relief to SCS for CRPS and causalgia of the lower limb. In the coming years we hope that randomized controlled trials will be performed on an indication-by-indication basis, which, together with the publication of longer term follow-up data, will provide a more complete understanding of the role of DRGS in the treatment of neuropathic pain syndromes.

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“…[85][86][87] In humans, epidural SCS implantation techniques were modified to bring electrodes in close apposition to dorsal nerve roots (the proximal dendrites of neurons), with some success in achieving adequate paresthesia coverage of painful areas and resultant pain relief. 88,89 Attempts to target the DRG directly for neuromodulation were laborious, 90 as gaining access to the foramen with conventional tools was cumbersome. Recently, a specially designed SCS system incorporating highly flexible small-diameter leads has been introduced, allowing electrodes to be apposed with the DRG cell bodies in the vertebral foramen via standard retrograde percutaneous placement under fluoroscopic guidance.…”

Section: Stimulation-based Therapiesmentioning

confidence: 99%

The Dorsal Root Ganglion as a Therapeutic Target for Chronic Pain

Liem

Dongen

Huygen

et al. 2016

Regional Anesthesia and Pain Medicine

100

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Chronic neuropathic pain is a widespread problem with negative personal and societal consequences. Despite considerable clinical neuroscience research, the goal of developing effective, reliable, and durable treatments has remained elusive. The critical role played by the dorsal root ganglion (DRG) in the induction and maintenance of chronic pain has been largely overlooked in these efforts, however. It may be that, by targeting this site, robust new options for pain management will be revealed. This review summarizes recent advances in the knowledge base for DRG-targeted treatments for neuropathic pain:• Pharmacological options including the chemical targeting of voltage-dependent calcium channels, transient receptor potential channels, neurotrophin production, potentiation of opioid transduction pathways, and excitatory glutamate receptors.• Ablation or modulation of the DRG via continuous thermal radiofrequency and pulsed radiofrequency treatments.• Implanted electrical neurostimulator technologies.• Interventions involving the modification of DRG cellular function at the genetic level by using viral vectors and gene silencing methods.

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Case Report: Successful Epiradicular Peripheral Nerve Stimulation of the C2 Dorsal Root Ganglion for Postherpetic Neuralgia

Cited by 45 publications

References 26 publications

Cervical and High-Thoracic Dorsal Root Ganglion Stimulation in Chronic Neuropathic Pain

Cervical and High-Thoracic Dorsal Root Ganglion Stimulation in Chronic Neuropathic Pain

The Efficacy and Safety of Dorsal Root Ganglion Stimulation as a Treatment for Neuropathic Pain: A Literature Review

The Dorsal Root Ganglion as a Therapeutic Target for Chronic Pain

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