“…Comprehensive preoperative screening and administration of hematopoietic stimulants, [9][10][11][12][13] clotting factors, 14,15 and RBC precursors 9,16,17 aim to optimize hemodynamics prior to surgery. The use of diathermy dissection, 17 hemostatic instruments, 18 limb tourniquets, 19 vascular occlusion devices, 20,21 hemostatic sealants, 22 and prohemostatic agents 10,12,23 have been demonstrated to reduce intraoperative blood loss. Hypotensive anesthesia, 24,25 hemodilution, 14,26 and autologous intraoperative blood salvage 27,28 further limit perioperative bleeding in JW.…”