Case Report: Venous Thromboembolism in AIDS

Becker, Daniel M.; Saunders, Timothy J.; Wispelwey, Brian; Schain, Denise C.

doi:10.1097/00000441-199206000-00008

Cited by 33 publications

(18 citation statements)

References 5 publications

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“…Other suggested risk factors for VTE in HIV-infected individuals include cytomegalovirus infection, Kaposi sarcoma, intravenous drug use (IVDU), and medication, including megesterol acetate, protease inhibitors, and erythropoietin. 1,15 In our 10 HIV1 VTE patients, two had a history of IVDU, four were on protease inhibitors, and one received erythropoietin.…”

Section: Hiv and Venous Thromboembolism 207mentioning

confidence: 93%

See 1 more Smart Citation

HIV Infection Is a Risk Factor for Venous Thromboembolism

Çopur¹,

Smith²,

Gómez³

et al. 2002

AIDS Patient Care and STDs

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The reported incidence of venous thromboembolism (VTE) in patients with human immunodeficiency virus (HIV) infection has ranged from 0.25 to 0.96% in clinical studies, but up to 17% at autopsy. A preliminary analysis at our hospital suggested that the frequency of VTE among HIV-positive individuals might be higher than previously reported. To further evaluate this issue, we performed a retrospective study of patients with a diagnosis of VTE and/or HIV infection discharged from our hospital between July 1, 1998 and June 30, 1999. A total of 13,496 patients were discharged during the year of the study. There were 244 patients with VTE and 362 who were HIV-positive. Ten of the 244 patients with VTE were HIV-positive (4.1%). The frequency of VTE among HIV-positive individuals was 10/362 (2.8%) compared to 234/13134 (1.8%) in the non-HIV-positive group, but the difference is not statistically significant. However, in patients under age 50, the frequencies were significantly different: 10/302 (3.31%) versus 35/6594 (0.53%), respectively (p < 0.0001). The frequency of VTE in HIV-positive patients less than 50 years old (3.31%) was greater than in HIV-positive patients over 50 years of age (0/60), but the difference did not reach statistical significance. In contrast, in the non-HIV-positive group, VTE was significantly more frequent in those 50 and older compared to younger patients (3.04% versus 0.53%, p = 0.0001). Statistical analysis indicated that the direction of association between age and diagnosis of VTE differed for HIV-positive patients versus non-HIV-positive patients. Our results suggest that HIV-positive patients under age 50 are at increased risk for VTE compared with non-HIV-positive individuals.

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Section: Hiv and Venous Thromboembolism 207mentioning

confidence: 93%

“…A POSSIBLE RELATION SHIP between HIV infection and venous thromboembolism (VTE) has been suggested in several case reports [1][2][3] and from autopsy data. 4,5 In contrast, clinical studies have not found a high incidence of VTE in HIV-positive (HIV1) individuals.…”

Section: Introductionmentioning

confidence: 99%

HIV Infection Is a Risk Factor for Venous Thromboembolism

Çopur¹,

Smith²,

Gómez³

et al. 2002

AIDS Patient Care and STDs

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show abstract

“…There are many reports of thrombosis occurring in patients with HIV/AIDS and these include peripheral vein, 56 57 pulmonary embolism, 56 retinal vein, 58-61 cerebral vein, 62 portal vein, 63 and mesenteric 64 65 occlusions. The occurrence of both arterial and venous thromboembolic disease has been reported in one patient by Bosson et al 66 It has become clear that in HIV infection, both types of aCL (the pathogenic or β 2 GPI dependent) as well as the non-pathogenic (non-β 2 GPI dependent) antibodies may be detected and that there is diversity, not only of the isotypes, but also of the aPL including antiphosphatidylserine antibodies.…”

Section: Cytomegalovirus (Cmv)mentioning

confidence: 99%

Antiphospholipid antibodies and infections

Asherson

Cervera²

2003

Annals of the Rheumatic Diseases

230

159

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“…There are many reports of thrombosis occurring in patients with HIV/AIDS and these include peripheral vein (Becker et al, 1992;Tanimowo, 1996), pulmonary embolism (Becker et al, 1992), retinal vein (Roberts and Haefs, 1992;Mansour et al, 1996;Park et al, 1997;Friedman and Margo, 1995), cerebral vein (Meyohas et al, 1998), portal vein (Carr et al, 1997) and mesenteric (Narayanan et al, 1998;Wang et al, 2000) occlusions. Both arterial and venous thromboembolic disease has been reported in one patient (Bosson et al, 1995).…”

Section: Human Immunodeficiency Virus (Hiv)mentioning

confidence: 99%