LETTER TO THE EDITORNerve dysfunction is commonly seen in patients with ALL, and may be related to central nervous symptom involvement by leukemia or side effects of chemotherapy drugs, particularly vincristine. 8 GBS is rarely recognized as a paraneoplastic phenomenon in cancer, and its presenting symptoms may be difficult to discern from more common causes of neurologic impairment. Its prompt recognition and GBS-specific therapy alongside cancer-directed therapy may allow for significant neurologic recovery.Autoantibody production and autoimmune effects have often been described in patients with Burkitt lymphoma, 9-11 but this phenomenon is recognized less often in B-cell ALL. B-cell ALL characterized by t(8;22) is a rarely encountered subtype that may be associated with a lymphomatous clinical presentation and production of autoantibodies responsible for paraneoplastic phenomena.