Case Reports of Cerebral Sinus Venous Thrombosis in COVID-19 Patients

Abstract

Background: The outbreak of Coronavirus disease 2019 (COVID-19) has started in China since December 2019 and expanding worldwide rapidly with cases of respiratory tract infection and multiple system involvement. Neurological manifestations are not exempted following the reports from various sources about Ischemic and haemorrhagic stroke related to COVID-19, but the reports about cerebral sinus venous thrombosis (CSVT) are still rare.Case presentation: We would like to report two cases of cerebral sinus venous thrombosis in COVID-19 patients following the respiratory manifestations with profound haematological and coagulation disarrangement triggered by COVID-19 and these are assumed as underlying mechanism. These two cases also have different course of disease and outcome which are interesting.Conclusions: CSVT is one of neurological complication and COVID -19 manifestation that can have grave prognosis, if this involves the brainstem venous drainage. Thrombogenesis and coagulation cascades are prolonged despite successful alteration to negative result of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) reverse transcription polymerase chain reaction (rt-PCR) test. Therefore, monitoring neutrophil to lymphocyte ration (NLR), D-dimer level, fibrinogen and C-reactive protein (CRP) is paramount as well as indicators of poor prognosis.